Analytical validity of a genotyping assay for use with personalized antihypertensive and chronic kidney disease therapy

Kimberly S. Collins, Victoria M. Pratt, Wesley M. Stansberry, Elizabeth B. Medeiros, Karthik Kannegolla, Marelize Swart, Todd C. Skaar, Arlene B. Chapman, Brian S. Decker, Ranjani N. Moorthi, Michael T. Eadon

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Hypertension and chronic kidney disease are inextricably linked. Hypertension is a well-recognized contributor to chronic kidney disease progression and, in turn, renal disease potentiates hypertension. A generalized approach to drug selection and dosage has not proven effective in managing these conditions, in part, because patients with heterogeneous kidney disease and hypertension etiologies are frequently grouped according to functional or severity classifications. Genetic testing may serve as an important tool in the armamentarium of clinicians who embrace precision medicine. Increasing scientific evidence has supported the utilization of genomic information to select efficacious antihypertensive therapy and understand hereditary contributors to chronic kidney disease progression. Given the wide array of antihypertensive agents available and diversity of genetic renal disease predictors, a panel-based approach to genotyping may be an efficient and economic means of establishing an individualized blood pressure response profile for patients with various forms of chronic kidney disease and hypertension. In this manuscript, we discuss the validation process of a Clinical Laboratory Improvement Amendments-approved genetic test to relay information on 72 genetic variants associated with kidney disease progression and hypertension therapy. These genomic-based interventions, in addition to routine clinical data, may help inform physicians to provide personalized therapy.

Original languageEnglish (US)
Pages (from-to)18-22
Number of pages5
JournalPharmacogenetics and Genomics
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2019

Keywords

  • Pharmacogenomics
  • chronic kidney disease
  • hypertension
  • implementation

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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