Anatomic distribution of pancreatic endocrine tumors

Thomas Howard, Bruce E. Stabile, Michael J. Zinner, Steven Chang, Belur S. Bhagavan, Edward Passaro

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Pancreatic endocrine tumors are grouped together by their common histologic, cytochemical, and ultrastructural features. Although useful conceptually, this paradigm has been unable to predict the anatomic location of different tumor types. Successful surgical excision of these tumors would be facilitated by an improved understanding of their anatomic distribution. Based on the available data, a bimodal distribution of pancreatic endocrine tumors was identified. Cluster 1 (gastrinomas, pancreatic polypeptide (PP)-secreting tumors, somatostatinomas) had 75% of tumors to the right of the superior mesenteric artery, whereas cluster 2 (insulinoma, glucagonoma) had 75% of tumors to the left of the superior mesenteric artery (p<0.05). This distribution is similar to that distribution predicted based on the volume density of the corresponding islet cells for insulinoma, glucagonoma, and PP-secreting tumors, but not for somatostatinoma. These findings suggest that pancreatic endocrine tumors are derived from similar cytologic precursors as pancreatic islet cells, and their distribution may be a consequence of embryologic development from either the ventral (cluster 1) or dorsal (cluster 2) pancreatic buds.

Original languageEnglish
Pages (from-to)258-264
Number of pages7
JournalAmerican Journal of Surgery
Volume159
Issue number2
DOIs
StatePublished - 1990
Externally publishedYes

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Neoplasms
Somatostatinoma
Islets of Langerhans
Glucagonoma
Pancreatic Polypeptide
Insulinoma
Superior Mesenteric Artery
Gastrinoma

ASJC Scopus subject areas

  • Surgery

Cite this

Howard, T., Stabile, B. E., Zinner, M. J., Chang, S., Bhagavan, B. S., & Passaro, E. (1990). Anatomic distribution of pancreatic endocrine tumors. American Journal of Surgery, 159(2), 258-264. https://doi.org/10.1016/S0002-9610(05)80276-4

Anatomic distribution of pancreatic endocrine tumors. / Howard, Thomas; Stabile, Bruce E.; Zinner, Michael J.; Chang, Steven; Bhagavan, Belur S.; Passaro, Edward.

In: American Journal of Surgery, Vol. 159, No. 2, 1990, p. 258-264.

Research output: Contribution to journalArticle

Howard, T, Stabile, BE, Zinner, MJ, Chang, S, Bhagavan, BS & Passaro, E 1990, 'Anatomic distribution of pancreatic endocrine tumors', American Journal of Surgery, vol. 159, no. 2, pp. 258-264. https://doi.org/10.1016/S0002-9610(05)80276-4
Howard, Thomas ; Stabile, Bruce E. ; Zinner, Michael J. ; Chang, Steven ; Bhagavan, Belur S. ; Passaro, Edward. / Anatomic distribution of pancreatic endocrine tumors. In: American Journal of Surgery. 1990 ; Vol. 159, No. 2. pp. 258-264.
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