Anatomic distribution of periprostatic adipose tissue

A mapping study of 100 radical prostatectomy specimens

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

BACKGROUND. Because the prostatic capsule is often indistinct, recognition of extraprostatic extension by carcinoma depends heavily on the identification of carcinoma cells in the periprostatic adipose tissue. However, the distribution of adipose tissue along the prostatic surfaces has not been studied extensively. METHODS. The authors analyzed the periprostatic adipose tissue in specimens from 100 patients treated with radical retropubic prostatectomy and bilateral pelvic lymphadenectomy for prostatecarcinoma. Each specimen was totally embedded and examined by the whole mount method. The presence or absence of adipose tissue on the anterior, posterior, right, and left surfaces of the prostate was determined and analyzed. RESULTS. Periprostatic adipose tissue was present on 48% of all prostatic surfaces examined. The distribution of periprostatic adipose tissue varied among the different surfaces of the prostate, with the anterior, posterior, right, and left surfaces showing 44%, 36%, 59%, and 57% adipose tissue, respectively. The amount of periprostatic adipose tissue was similar among specimens from operations performed by different surgeons (P = 0.72). However, nerve-sparing procedures resulted in less adipose tissue (46%) than non-nerve-sparing procedures (54%) (P = 0.01). CONCLUSIONS. Less than half of the prostatic surfaces examined were covered by adipose tissue. The absence of adipose tissue over large areas of the prostatic surface, especially the posterior surface, makes the evaluation of extraprostatic extension difficult and unreliable. Further refinement of the prostate carcinoma staging system is needed.

Original languageEnglish
Pages (from-to)1639-1643
Number of pages5
JournalCancer
Volume97
Issue number7
DOIs
StatePublished - Apr 1 2003

Fingerprint

Prostatectomy
Adipose Tissue
Prostate
Carcinoma
Lymph Node Excision
Capsules

Keywords

  • Extraprostatic extension
  • Neoplasms
  • Periprostatic adipose tissue
  • Prostate
  • Radical prostatectomy
  • Staging

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

@article{3a1602fbcb47437a847dada208c7658a,
title = "Anatomic distribution of periprostatic adipose tissue: A mapping study of 100 radical prostatectomy specimens",
abstract = "BACKGROUND. Because the prostatic capsule is often indistinct, recognition of extraprostatic extension by carcinoma depends heavily on the identification of carcinoma cells in the periprostatic adipose tissue. However, the distribution of adipose tissue along the prostatic surfaces has not been studied extensively. METHODS. The authors analyzed the periprostatic adipose tissue in specimens from 100 patients treated with radical retropubic prostatectomy and bilateral pelvic lymphadenectomy for prostatecarcinoma. Each specimen was totally embedded and examined by the whole mount method. The presence or absence of adipose tissue on the anterior, posterior, right, and left surfaces of the prostate was determined and analyzed. RESULTS. Periprostatic adipose tissue was present on 48{\%} of all prostatic surfaces examined. The distribution of periprostatic adipose tissue varied among the different surfaces of the prostate, with the anterior, posterior, right, and left surfaces showing 44{\%}, 36{\%}, 59{\%}, and 57{\%} adipose tissue, respectively. The amount of periprostatic adipose tissue was similar among specimens from operations performed by different surgeons (P = 0.72). However, nerve-sparing procedures resulted in less adipose tissue (46{\%}) than non-nerve-sparing procedures (54{\%}) (P = 0.01). CONCLUSIONS. Less than half of the prostatic surfaces examined were covered by adipose tissue. The absence of adipose tissue over large areas of the prostatic surface, especially the posterior surface, makes the evaluation of extraprostatic extension difficult and unreliable. Further refinement of the prostate carcinoma staging system is needed.",
keywords = "Extraprostatic extension, Neoplasms, Periprostatic adipose tissue, Prostate, Radical prostatectomy, Staging",
author = "Heng Hong and Michael Koch and Richard Foster and Richard Bihrle and Thomas Gardner and Joanne Daggy and Thomas Ulbright and John Eble and Liang Cheng",
year = "2003",
month = "4",
day = "1",
doi = "10.1002/cncr.11231",
language = "English",
volume = "97",
pages = "1639--1643",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "7",

}

TY - JOUR

T1 - Anatomic distribution of periprostatic adipose tissue

T2 - A mapping study of 100 radical prostatectomy specimens

AU - Hong, Heng

AU - Koch, Michael

AU - Foster, Richard

AU - Bihrle, Richard

AU - Gardner, Thomas

AU - Daggy, Joanne

AU - Ulbright, Thomas

AU - Eble, John

AU - Cheng, Liang

PY - 2003/4/1

Y1 - 2003/4/1

N2 - BACKGROUND. Because the prostatic capsule is often indistinct, recognition of extraprostatic extension by carcinoma depends heavily on the identification of carcinoma cells in the periprostatic adipose tissue. However, the distribution of adipose tissue along the prostatic surfaces has not been studied extensively. METHODS. The authors analyzed the periprostatic adipose tissue in specimens from 100 patients treated with radical retropubic prostatectomy and bilateral pelvic lymphadenectomy for prostatecarcinoma. Each specimen was totally embedded and examined by the whole mount method. The presence or absence of adipose tissue on the anterior, posterior, right, and left surfaces of the prostate was determined and analyzed. RESULTS. Periprostatic adipose tissue was present on 48% of all prostatic surfaces examined. The distribution of periprostatic adipose tissue varied among the different surfaces of the prostate, with the anterior, posterior, right, and left surfaces showing 44%, 36%, 59%, and 57% adipose tissue, respectively. The amount of periprostatic adipose tissue was similar among specimens from operations performed by different surgeons (P = 0.72). However, nerve-sparing procedures resulted in less adipose tissue (46%) than non-nerve-sparing procedures (54%) (P = 0.01). CONCLUSIONS. Less than half of the prostatic surfaces examined were covered by adipose tissue. The absence of adipose tissue over large areas of the prostatic surface, especially the posterior surface, makes the evaluation of extraprostatic extension difficult and unreliable. Further refinement of the prostate carcinoma staging system is needed.

AB - BACKGROUND. Because the prostatic capsule is often indistinct, recognition of extraprostatic extension by carcinoma depends heavily on the identification of carcinoma cells in the periprostatic adipose tissue. However, the distribution of adipose tissue along the prostatic surfaces has not been studied extensively. METHODS. The authors analyzed the periprostatic adipose tissue in specimens from 100 patients treated with radical retropubic prostatectomy and bilateral pelvic lymphadenectomy for prostatecarcinoma. Each specimen was totally embedded and examined by the whole mount method. The presence or absence of adipose tissue on the anterior, posterior, right, and left surfaces of the prostate was determined and analyzed. RESULTS. Periprostatic adipose tissue was present on 48% of all prostatic surfaces examined. The distribution of periprostatic adipose tissue varied among the different surfaces of the prostate, with the anterior, posterior, right, and left surfaces showing 44%, 36%, 59%, and 57% adipose tissue, respectively. The amount of periprostatic adipose tissue was similar among specimens from operations performed by different surgeons (P = 0.72). However, nerve-sparing procedures resulted in less adipose tissue (46%) than non-nerve-sparing procedures (54%) (P = 0.01). CONCLUSIONS. Less than half of the prostatic surfaces examined were covered by adipose tissue. The absence of adipose tissue over large areas of the prostatic surface, especially the posterior surface, makes the evaluation of extraprostatic extension difficult and unreliable. Further refinement of the prostate carcinoma staging system is needed.

KW - Extraprostatic extension

KW - Neoplasms

KW - Periprostatic adipose tissue

KW - Prostate

KW - Radical prostatectomy

KW - Staging

UR - http://www.scopus.com/inward/record.url?scp=0037377722&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037377722&partnerID=8YFLogxK

U2 - 10.1002/cncr.11231

DO - 10.1002/cncr.11231

M3 - Article

VL - 97

SP - 1639

EP - 1643

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 7

ER -