Anatomic distribution of pulmonary vascular compliance

Robert G. Presson, Said H. Audi, Christopher C. Hanger, Gerald M. Zenk, Richard A. Sidner, John H. Linehan, Wiltz W. Wagner, Christopher A. Dawson

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Previously, the pressure changes after arterial and venous occlusion have been used to characterize the longitudinal distribution of pulmonary vascular resistance with respect to vascular compliance using compartmental models. However, the compartments have not been defined anatomically. Using video microscopy of the subpleural microcirculation, we have measured the flow changes in ~40-μm arterioles and venules after venous, arterial, and double occlusion maneuvers. The quasi-steady flows through these vessels after venous occlusion permitted an estimation of the compliance in three anatomic segments: arteries >40 μm, veins >40 μm, and vessels <40 μm in diameter. We found that ~65% of the total pulmonary vascular compliance was in vessels <40 μm, presumably mostly capillaries. The transient portions of the pressure and flow data after venous, arterial, and double occlusion were consistent with most of the arterial compliance being upstream from most of the arterial resistance and most of the venous compliance being downstream from most of the venous resistance.

Original languageEnglish (US)
Pages (from-to)303-310
Number of pages8
JournalJournal of Applied Physiology
Volume84
Issue number1
DOIs
StatePublished - Jan 1998

Keywords

  • Arterial occlusion
  • Digital image analysis
  • Double occlusion
  • Fluorescently labeled red blood cells
  • Isolated dog lung
  • Mathematical model
  • Pulmonary microcirculation
  • Vascular resistance
  • Venous occlusion
  • Video fluorescence microscopy

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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  • Cite this

    Presson, R. G., Audi, S. H., Hanger, C. C., Zenk, G. M., Sidner, R. A., Linehan, J. H., Wagner, W. W., & Dawson, C. A. (1998). Anatomic distribution of pulmonary vascular compliance. Journal of Applied Physiology, 84(1), 303-310. https://doi.org/10.1152/jappl.1998.84.1.303