This chapter presents preliminary results on studies of the cortical and thalamic innervation of neostriatal grafts, including the spatial distribution of synaptic terminals arising from single axons, the morphological characteristics of the synapses formed in the grafts, and the varieties of physiological responses evoked in the grafts by stimulation of these inputs. The morphological features of Phaseolus leukoagglutinin (PHAL) stained corticostriatal and thalamostriatal axons in a neostriatal graft and of afferents from the host labeled by the same injections. The characteristic pattern of corticostriatal and thalamostriatal axonal arborizations in normal adult neostriatum is seen throughout the host tissue. Afferent axons form a meshwork of extremely fine, relatively straight, and unbranched axons that coursed for long distances through the neostriatum. In contrast, cortical and thalamic axons in the grafts formed focal arborizations in which a relatively coarse main axonal branch gives rise to the clusters of fine terminal side branches that form many boutons in a very confined volume.
ASJC Scopus subject areas