Androgen receptor-driven chromatin looping in prostate cancer

Dayong Wu, Chunpeng Zhang, Yanping Shen, Kenneth P. Nephew, Qianben Wang

Research output: Contribution to journalReview article

34 Scopus citations

Abstract

The androgen receptor (AR) is important for prostate cancer development and progression. Genome-wide mapping of AR binding sites in prostate cancer has found that the majority of AR binding sites are located within non-promoter regions. These distal AR binding regions regulate AR target genes (e.g. UBE2C) involved in prostate cancer growth through chromatin looping. In addition to long-distance gene regulation, looping has been shown to induce spatial proximity of two genes otherwise located far away along the genomic sequence and the formation of double-strand DNA breaks, resulting in aberrant gene fusions (e.g. TMPRSS2-ERG) that also contribute to prostate tumorigenesis. Elucidating the mechanisms of AR-driven chromatin looping will increase our understanding of prostate carcinogenesis and may lead to the identification of new therapeutic targets.

Original languageEnglish (US)
Pages (from-to)474-480
Number of pages7
JournalTrends in Endocrinology and Metabolism
Volume22
Issue number12
DOIs
StatePublished - Dec 1 2011

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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