Androgen regulation of axon growth and neurite extension in motoneurons

Keith N. Fargo, Mariarita Galbiati, Eileen M. Foecking, Angelo Poletti, Kathryn J. Jones

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Androgens act on the CNS to affect motor function through interaction with a widespread distribution of intracellular androgen receptors (AR). This review highlights our work on androgens and process outgrowth in motoneurons, both in vitro and in vivo. The actions of androgens on motoneurons involve the generation of novel neuronal interactions that are mediated by the induction of androgen-dependent neurite or axonal outgrowth. Here, we summarize the experimental evidence for the androgenic regulation of the extension and regeneration of motoneuron neurites in vitro using cultured immortalized motoneurons, and axons in vivo using the hamster facial nerve crush paradigm. We place particular emphasis on the relevance of these effects to SBMA and peripheral nerve injuries.

Original languageEnglish (US)
Pages (from-to)716-728
Number of pages13
JournalHormones and Behavior
Volume53
Issue number5
DOIs
StatePublished - May 1 2008

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Keywords

  • Androgens
  • Gonadal steroids
  • Motoneuron disease
  • Motoneurons
  • Peripheral nerve injury
  • Spinal cord injury

ASJC Scopus subject areas

  • Endocrinology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

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