Androgen regulation of axon growth and neurite extension in motoneurons

Keith N. Fargo, Mariarita Galbiati, Eileen M. Foecking, Angelo Poletti, Kathryn Jones

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Androgens act on the CNS to affect motor function through interaction with a widespread distribution of intracellular androgen receptors (AR). This review highlights our work on androgens and process outgrowth in motoneurons, both in vitro and in vivo. The actions of androgens on motoneurons involve the generation of novel neuronal interactions that are mediated by the induction of androgen-dependent neurite or axonal outgrowth. Here, we summarize the experimental evidence for the androgenic regulation of the extension and regeneration of motoneuron neurites in vitro using cultured immortalized motoneurons, and axons in vivo using the hamster facial nerve crush paradigm. We place particular emphasis on the relevance of these effects to SBMA and peripheral nerve injuries.

Original languageEnglish (US)
Pages (from-to)716-728
Number of pages13
JournalHormones and Behavior
Volume53
Issue number5
DOIs
StatePublished - May 2008
Externally publishedYes

Fingerprint

Motor Neurons
Neurites
Androgens
Axons
Growth
Nerve Crush
Peripheral Nerve Injuries
Facial Nerve
Androgen Receptors
Cricetinae
Regeneration
In Vitro Techniques

Keywords

  • Androgens
  • Gonadal steroids
  • Motoneuron disease
  • Motoneurons
  • Peripheral nerve injury
  • Spinal cord injury

ASJC Scopus subject areas

  • Endocrinology
  • Behavioral Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Androgen regulation of axon growth and neurite extension in motoneurons. / Fargo, Keith N.; Galbiati, Mariarita; Foecking, Eileen M.; Poletti, Angelo; Jones, Kathryn.

In: Hormones and Behavior, Vol. 53, No. 5, 05.2008, p. 716-728.

Research output: Contribution to journalArticle

Fargo, Keith N. ; Galbiati, Mariarita ; Foecking, Eileen M. ; Poletti, Angelo ; Jones, Kathryn. / Androgen regulation of axon growth and neurite extension in motoneurons. In: Hormones and Behavior. 2008 ; Vol. 53, No. 5. pp. 716-728.
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