Androgenic regulation of the central glia response following nerve damage

Kathryn J. Jones, Susanna Coers, Paul D. Storer, Lisa Tanzer, Nancy B. Kinderman

Research output: Contribution to journalReview article

40 Scopus citations


Current research on the effects of gonadal steroids on the brain and spinal cord indicates that these agents have profound trophic effects on many aspects of neuronal functioning, including cell survival, growth and metabolism, elaboration of processes, synaptogenesis, and neurotransmission (Jones et al., 1985; Luine, 1985; Nordeen et al., 1985; Matsumoto et al., 1988a,b; Gould et al., 1990). Since many of the aspects of normal neuronal functioning altered by gonadal steroids are affected by injury to the nervous system, we initiated a series of experiments designed to exploit the trophic capabilities of steroids as therapeutic agents in neuronal injury and repair (Kujawa et al., 1989, 1991; Kujawa and Jones, 1990). Three steroid-sensitive model systems were used for these studies: the hamster facial motoneuron, the rat sciatic motoneuron, and the hamster rubrospinal motoneuron. The results of our initial series of experiments suggest that androgens, and possibly estrogens, act either directly or indirectly on the injured motoneuron and enhance elements of the neuronal reparative response that are critical to successful recovery of function. Recently, we discovered that gonadal steroids may also modulate the central glia response to nerve damage. In this review, a summary of our data identifying a therapeutic role for androgens in enhancing the reparative response of motoneurons to injury is presented. This is followed by a discussion of the effects of androgens on the glial response to injury.

Original languageEnglish (US)
Pages (from-to)560-573
Number of pages14
JournalJournal of Neurobiology
Issue number4
StatePublished - Sep 15 1999
Externally publishedYes


  • Axotomy
  • Facial motoneuron
  • Glial fibrillary acidic protein
  • Red nucleus
  • Sciatic motoneuron
  • Synaptic stripping
  • Testosterone

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Androgenic regulation of the central glia response following nerve damage'. Together they form a unique fingerprint.

  • Cite this