Androgenic regulation of the central glia response following nerve damage

Kathryn Jones, Susanna Coers, Paul D. Storer, Lisa Tanzer, Nancy B. Kinderman

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Current research on the effects of gonadal steroids on the brain and spinal cord indicates that these agents have profound trophic effects on many aspects of neuronal functioning, including cell survival, growth and metabolism, elaboration of processes, synaptogenesis, and neurotransmission (Jones et al., 1985; Luine, 1985; Nordeen et al., 1985; Matsumoto et al., 1988a,b; Gould et al., 1990). Since many of the aspects of normal neuronal functioning altered by gonadal steroids are affected by injury to the nervous system, we initiated a series of experiments designed to exploit the trophic capabilities of steroids as therapeutic agents in neuronal injury and repair (Kujawa et al., 1989, 1991; Kujawa and Jones, 1990). Three steroid-sensitive model systems were used for these studies: the hamster facial motoneuron, the rat sciatic motoneuron, and the hamster rubrospinal motoneuron. The results of our initial series of experiments suggest that androgens, and possibly estrogens, act either directly or indirectly on the injured motoneuron and enhance elements of the neuronal reparative response that are critical to successful recovery of function. Recently, we discovered that gonadal steroids may also modulate the central glia response to nerve damage. In this review, a summary of our data identifying a therapeutic role for androgens in enhancing the reparative response of motoneurons to injury is presented. This is followed by a discussion of the effects of androgens on the glial response to injury.

Original languageEnglish (US)
Pages (from-to)560-573
Number of pages14
JournalJournal of Neurobiology
Volume40
Issue number4
DOIs
StatePublished - Sep 15 1999
Externally publishedYes

Fingerprint

Motor Neurons
Neuroglia
Steroids
Androgens
Cricetinae
Wounds and Injuries
Nervous System Trauma
Recovery of Function
Synaptic Transmission
Cell Survival
Spinal Cord
Estrogens
Brain
Therapeutics
Growth
Research

Keywords

  • Axotomy
  • Facial motoneuron
  • Glial fibrillary acidic protein
  • Red nucleus
  • Sciatic motoneuron
  • Synaptic stripping
  • Testosterone

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Androgenic regulation of the central glia response following nerve damage. / Jones, Kathryn; Coers, Susanna; Storer, Paul D.; Tanzer, Lisa; Kinderman, Nancy B.

In: Journal of Neurobiology, Vol. 40, No. 4, 15.09.1999, p. 560-573.

Research output: Contribution to journalArticle

Jones, Kathryn ; Coers, Susanna ; Storer, Paul D. ; Tanzer, Lisa ; Kinderman, Nancy B. / Androgenic regulation of the central glia response following nerve damage. In: Journal of Neurobiology. 1999 ; Vol. 40, No. 4. pp. 560-573.
@article{e0631b9777eb43e9a7c2c0bdba9008bc,
title = "Androgenic regulation of the central glia response following nerve damage",
abstract = "Current research on the effects of gonadal steroids on the brain and spinal cord indicates that these agents have profound trophic effects on many aspects of neuronal functioning, including cell survival, growth and metabolism, elaboration of processes, synaptogenesis, and neurotransmission (Jones et al., 1985; Luine, 1985; Nordeen et al., 1985; Matsumoto et al., 1988a,b; Gould et al., 1990). Since many of the aspects of normal neuronal functioning altered by gonadal steroids are affected by injury to the nervous system, we initiated a series of experiments designed to exploit the trophic capabilities of steroids as therapeutic agents in neuronal injury and repair (Kujawa et al., 1989, 1991; Kujawa and Jones, 1990). Three steroid-sensitive model systems were used for these studies: the hamster facial motoneuron, the rat sciatic motoneuron, and the hamster rubrospinal motoneuron. The results of our initial series of experiments suggest that androgens, and possibly estrogens, act either directly or indirectly on the injured motoneuron and enhance elements of the neuronal reparative response that are critical to successful recovery of function. Recently, we discovered that gonadal steroids may also modulate the central glia response to nerve damage. In this review, a summary of our data identifying a therapeutic role for androgens in enhancing the reparative response of motoneurons to injury is presented. This is followed by a discussion of the effects of androgens on the glial response to injury.",
keywords = "Axotomy, Facial motoneuron, Glial fibrillary acidic protein, Red nucleus, Sciatic motoneuron, Synaptic stripping, Testosterone",
author = "Kathryn Jones and Susanna Coers and Storer, {Paul D.} and Lisa Tanzer and Kinderman, {Nancy B.}",
year = "1999",
month = "9",
day = "15",
doi = "10.1002/(SICI)1097-4695(19990915)40:4<560::AID-NEU11>3.0.CO;2-I",
language = "English (US)",
volume = "40",
pages = "560--573",
journal = "Developmental Neurobiology",
issn = "1932-8451",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Androgenic regulation of the central glia response following nerve damage

AU - Jones, Kathryn

AU - Coers, Susanna

AU - Storer, Paul D.

AU - Tanzer, Lisa

AU - Kinderman, Nancy B.

PY - 1999/9/15

Y1 - 1999/9/15

N2 - Current research on the effects of gonadal steroids on the brain and spinal cord indicates that these agents have profound trophic effects on many aspects of neuronal functioning, including cell survival, growth and metabolism, elaboration of processes, synaptogenesis, and neurotransmission (Jones et al., 1985; Luine, 1985; Nordeen et al., 1985; Matsumoto et al., 1988a,b; Gould et al., 1990). Since many of the aspects of normal neuronal functioning altered by gonadal steroids are affected by injury to the nervous system, we initiated a series of experiments designed to exploit the trophic capabilities of steroids as therapeutic agents in neuronal injury and repair (Kujawa et al., 1989, 1991; Kujawa and Jones, 1990). Three steroid-sensitive model systems were used for these studies: the hamster facial motoneuron, the rat sciatic motoneuron, and the hamster rubrospinal motoneuron. The results of our initial series of experiments suggest that androgens, and possibly estrogens, act either directly or indirectly on the injured motoneuron and enhance elements of the neuronal reparative response that are critical to successful recovery of function. Recently, we discovered that gonadal steroids may also modulate the central glia response to nerve damage. In this review, a summary of our data identifying a therapeutic role for androgens in enhancing the reparative response of motoneurons to injury is presented. This is followed by a discussion of the effects of androgens on the glial response to injury.

AB - Current research on the effects of gonadal steroids on the brain and spinal cord indicates that these agents have profound trophic effects on many aspects of neuronal functioning, including cell survival, growth and metabolism, elaboration of processes, synaptogenesis, and neurotransmission (Jones et al., 1985; Luine, 1985; Nordeen et al., 1985; Matsumoto et al., 1988a,b; Gould et al., 1990). Since many of the aspects of normal neuronal functioning altered by gonadal steroids are affected by injury to the nervous system, we initiated a series of experiments designed to exploit the trophic capabilities of steroids as therapeutic agents in neuronal injury and repair (Kujawa et al., 1989, 1991; Kujawa and Jones, 1990). Three steroid-sensitive model systems were used for these studies: the hamster facial motoneuron, the rat sciatic motoneuron, and the hamster rubrospinal motoneuron. The results of our initial series of experiments suggest that androgens, and possibly estrogens, act either directly or indirectly on the injured motoneuron and enhance elements of the neuronal reparative response that are critical to successful recovery of function. Recently, we discovered that gonadal steroids may also modulate the central glia response to nerve damage. In this review, a summary of our data identifying a therapeutic role for androgens in enhancing the reparative response of motoneurons to injury is presented. This is followed by a discussion of the effects of androgens on the glial response to injury.

KW - Axotomy

KW - Facial motoneuron

KW - Glial fibrillary acidic protein

KW - Red nucleus

KW - Sciatic motoneuron

KW - Synaptic stripping

KW - Testosterone

UR - http://www.scopus.com/inward/record.url?scp=0033567837&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033567837&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-4695(19990915)40:4<560::AID-NEU11>3.0.CO;2-I

DO - 10.1002/(SICI)1097-4695(19990915)40:4<560::AID-NEU11>3.0.CO;2-I

M3 - Article

VL - 40

SP - 560

EP - 573

JO - Developmental Neurobiology

JF - Developmental Neurobiology

SN - 1932-8451

IS - 4

ER -