Angiotensin-converting enzyme activity in tissues of the rainbow trout.

R. Galardy, P. Podhasky, Kenneth Olson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Angiotensin-converting enzyme activity (ACE) was assayed in homogenized rainbow trout tissues and plasma. The physiological role of ACE was examined by injection of the ACE inhibitor captopril (SQ 14,225) into the dorsal aorta of chronically cannulated trout. Gills and corpuscles of Stannius exhibited greatest ACE activity and contained over 30 times more enzyme than plasma on a per-wet-weight basis. ACE was barely detectable in skeletal muscle, liver, and kidney tissues. Captopril lowered dorsal aortic pressure (DAP) within 1 min after injection. Pressure fell 5-7 mm Hg below control over the next 30 min and remained at this level for an additional hour. Because the gills receive the entire cardiac output they are, like the mammalian lungs, ideally situated to regulate plasma hormone levels. Activation of angiotensin II (AII) appears to be only one example of branchial metabolic capability.

Original languageEnglish
Pages (from-to)155-158
Number of pages4
JournalJournal of Experimental Zoology
Volume230
Issue number1
StatePublished - Apr 1984

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peptidyl-dipeptidase A
Oncorhynchus mykiss
enzyme activity
gills
injection
angiotensin II
cardiac output
aorta
trout
skeletal muscle
lungs
kidneys
hormones
tissues
liver
enzymes

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Angiotensin-converting enzyme activity in tissues of the rainbow trout. / Galardy, R.; Podhasky, P.; Olson, Kenneth.

In: Journal of Experimental Zoology, Vol. 230, No. 1, 04.1984, p. 155-158.

Research output: Contribution to journalArticle

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