Angiotensin I-converting enzyme (ACE) gene structure and polymorphism: Relation to enzyme function and gene expression

Florent Soubrier, Lei Wei, Christine Hubert, Eric Clauser, François Alhenc-Gelas, Pierre Corvol

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Angiotensin I-converting enzyme (ACE; Kininase II, dipeptidyl-carboxy-peptidase I; EC 3.4.15.1) acts primarily as a dipeptidyl carboxypeptidase and is involved in the metabolism of two major vasoactive peptides, angiotensin II and bradykinin. ACE generates the potent vasopressor angiotensin II (AII) by cleaving the C-terminal dipeptide from angiotensin I (AI) and inactivates the vasodepressor bradykinin (BK), by the sequential removal of two C-terminal dipeptides. 1 The most favorable ACE substrate is BK (Km: 0.2 μM) for which the Km is approximately 80 times lower than for AI (Km: 16 μM).

Original languageEnglish (US)
Title of host publicationCellular and Molecular Biology of the Renin-Angiotensin System
PublisherCRC Press
Pages221-242
Number of pages22
ISBN (Electronic)9781351078948
ISBN (Print)9781315891392
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

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Peptidyl-Dipeptidase A
Polymorphism
Gene expression
Genes
Gene Expression
Bradykinin
Enzymes
Angiotensin I
Dipeptides
Angiotensin II
Cathepsin C
Metabolism
Peptide Hydrolases
Peptides
Substrates

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Soubrier, F., Wei, L., Hubert, C., Clauser, E., Alhenc-Gelas, F., & Corvol, P. (2018). Angiotensin I-converting enzyme (ACE) gene structure and polymorphism: Relation to enzyme function and gene expression. In Cellular and Molecular Biology of the Renin-Angiotensin System (pp. 221-242). CRC Press. https://doi.org/10.1201/9781351070492

Angiotensin I-converting enzyme (ACE) gene structure and polymorphism : Relation to enzyme function and gene expression. / Soubrier, Florent; Wei, Lei; Hubert, Christine; Clauser, Eric; Alhenc-Gelas, François; Corvol, Pierre.

Cellular and Molecular Biology of the Renin-Angiotensin System. CRC Press, 2018. p. 221-242.

Research output: Chapter in Book/Report/Conference proceedingChapter

Soubrier, F, Wei, L, Hubert, C, Clauser, E, Alhenc-Gelas, F & Corvol, P 2018, Angiotensin I-converting enzyme (ACE) gene structure and polymorphism: Relation to enzyme function and gene expression. in Cellular and Molecular Biology of the Renin-Angiotensin System. CRC Press, pp. 221-242. https://doi.org/10.1201/9781351070492
Soubrier F, Wei L, Hubert C, Clauser E, Alhenc-Gelas F, Corvol P. Angiotensin I-converting enzyme (ACE) gene structure and polymorphism: Relation to enzyme function and gene expression. In Cellular and Molecular Biology of the Renin-Angiotensin System. CRC Press. 2018. p. 221-242 https://doi.org/10.1201/9781351070492
Soubrier, Florent ; Wei, Lei ; Hubert, Christine ; Clauser, Eric ; Alhenc-Gelas, François ; Corvol, Pierre. / Angiotensin I-converting enzyme (ACE) gene structure and polymorphism : Relation to enzyme function and gene expression. Cellular and Molecular Biology of the Renin-Angiotensin System. CRC Press, 2018. pp. 221-242
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