Angiotensin I-converting enzyme (ACE; Kininase II, dipeptidyl-carboxy-peptidase I; EC 126.96.36.199) acts primarily as a dipeptidyl carboxypeptidase and is involved in the metabolism of two major vasoactive peptides, angiotensin II and bradykinin. ACE generates the potent vasopressor angiotensin II (AII) by cleaving the C-terminal dipeptide from angiotensin I (AI) and inactivates the vasodepressor bradykinin (BK), by the sequential removal of two C-terminal dipeptides. 1 The most favorable ACE substrate is BK (Km: 0.2 μM) for which the Km is approximately 80 times lower than for AI (Km: 16 μM).
|Original language||English (US)|
|Title of host publication||Cellular and Molecular Biology of the Renin-Angiotensin System|
|Number of pages||22|
|State||Published - Jan 1 2018|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)