Animal housing influences the response of bone to spaceflight in juvenile rats

Emily R. Morey-Holton, Bernard P. Halloran, Lawrence P. Garetto, Stephen B. Doty

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The rat has been used extensively as an animal model to study the effects of spaceflight on bone metabolism. The results of these studies have been inconsistent. On some missions, bone formation at the periosteal bone surface of weight-bearing bones is impaired and on others it is not, suggesting that experimental conditions may be an important determinant of bone responsiveness to spaceflight. To determine whether animal housing can affect the response of bone to spaceflight, we studied young growing (juvenile) rats group housed in the animal enclosure module and singly housed in the research animal holding facility under otherwise identical flight conditions (Spacelab Life Science 1). Spaceflight reduced periosteal bone formation by 30% (P <0.001) and bone mass by 7% in single-housed animals but had little or no effect on formation (6%) or mass (3%) in group-housed animals. Group housing reduced the response of bone to spaceflight by as much as 80%. The data suggest that housing can dramatically affect the skeletal response of juvenile rats to spaceflight. These observations explain many of the discrepancies in previous flight studies and emphasize the need to study more closely the effects of housing (physical-social interaction) on the response of bone to the weightlessness of spaceflight.

Original languageEnglish (US)
Pages (from-to)1303-1309
Number of pages7
JournalJournal of Applied Physiology
Volume88
Issue number4
StatePublished - 2000
Externally publishedYes

Fingerprint

Animal Housing
Space Flight
Bone and Bones
Osteogenesis
Weightlessness
Biological Science Disciplines
Weight-Bearing
Interpersonal Relations
Animal Models

Keywords

  • Osteoporosis
  • Weightlessness

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Morey-Holton, E. R., Halloran, B. P., Garetto, L. P., & Doty, S. B. (2000). Animal housing influences the response of bone to spaceflight in juvenile rats. Journal of Applied Physiology, 88(4), 1303-1309.

Animal housing influences the response of bone to spaceflight in juvenile rats. / Morey-Holton, Emily R.; Halloran, Bernard P.; Garetto, Lawrence P.; Doty, Stephen B.

In: Journal of Applied Physiology, Vol. 88, No. 4, 2000, p. 1303-1309.

Research output: Contribution to journalArticle

Morey-Holton, ER, Halloran, BP, Garetto, LP & Doty, SB 2000, 'Animal housing influences the response of bone to spaceflight in juvenile rats', Journal of Applied Physiology, vol. 88, no. 4, pp. 1303-1309.
Morey-Holton ER, Halloran BP, Garetto LP, Doty SB. Animal housing influences the response of bone to spaceflight in juvenile rats. Journal of Applied Physiology. 2000;88(4):1303-1309.
Morey-Holton, Emily R. ; Halloran, Bernard P. ; Garetto, Lawrence P. ; Doty, Stephen B. / Animal housing influences the response of bone to spaceflight in juvenile rats. In: Journal of Applied Physiology. 2000 ; Vol. 88, No. 4. pp. 1303-1309.
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