Abstract
An animal model of Graves' disease (GD) will help us to clearly understand the role of thyroid-stimulating hormone receptor (TSHR)-specific T cells and TSHR-Abs during the development of GD and to develop TSHR-specific immunotherapy. This review focuses on four different recent approaches towards the development of an animal model of GD. These approaches are: (1) Immunization of AKR/N mice with fibroblasts coexpressing syngeneic major histocompatibility complex (MHC) class II and TSHR. (2) Immunization of selected strains of mice with an expression vector containing TSHR cDNA. (3) Immunization of BALB/c mice with syngeneic M12 cells or xenogenic HEK-293 cells expressing full-length or extracellular domain of TSHR (ETSHR). (4) Injection of adenovirus-expressing TSHR into BALB/c mice.
| Original language | English |
|---|---|
| Pages (from-to) | 381-387 |
| Number of pages | 7 |
| Journal | Autoimmunity |
| Volume | 36 |
| Issue number | 6-7 |
| DOIs | |
| State | Published - Sep 2003 |
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Keywords
- Animal model
- Graves' disease
- Hyperthyroidism
- TSHR autoantibodies
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Animal models of Graves' hyperthyroidism. / Seetharamaiah, Gattadahalli.
In: Autoimmunity, Vol. 36, No. 6-7, 09.2003, p. 381-387.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Animal models of Graves' hyperthyroidism
AU - Seetharamaiah, Gattadahalli
PY - 2003/9
Y1 - 2003/9
N2 - An animal model of Graves' disease (GD) will help us to clearly understand the role of thyroid-stimulating hormone receptor (TSHR)-specific T cells and TSHR-Abs during the development of GD and to develop TSHR-specific immunotherapy. This review focuses on four different recent approaches towards the development of an animal model of GD. These approaches are: (1) Immunization of AKR/N mice with fibroblasts coexpressing syngeneic major histocompatibility complex (MHC) class II and TSHR. (2) Immunization of selected strains of mice with an expression vector containing TSHR cDNA. (3) Immunization of BALB/c mice with syngeneic M12 cells or xenogenic HEK-293 cells expressing full-length or extracellular domain of TSHR (ETSHR). (4) Injection of adenovirus-expressing TSHR into BALB/c mice.
AB - An animal model of Graves' disease (GD) will help us to clearly understand the role of thyroid-stimulating hormone receptor (TSHR)-specific T cells and TSHR-Abs during the development of GD and to develop TSHR-specific immunotherapy. This review focuses on four different recent approaches towards the development of an animal model of GD. These approaches are: (1) Immunization of AKR/N mice with fibroblasts coexpressing syngeneic major histocompatibility complex (MHC) class II and TSHR. (2) Immunization of selected strains of mice with an expression vector containing TSHR cDNA. (3) Immunization of BALB/c mice with syngeneic M12 cells or xenogenic HEK-293 cells expressing full-length or extracellular domain of TSHR (ETSHR). (4) Injection of adenovirus-expressing TSHR into BALB/c mice.
KW - Animal model
KW - Graves' disease
KW - Hyperthyroidism
KW - TSHR autoantibodies
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UR - http://www.scopus.com/inward/citedby.url?scp=0141481280&partnerID=8YFLogxK
U2 - 10.1080/08916930310001602966
DO - 10.1080/08916930310001602966
M3 - Article
VL - 36
SP - 381
EP - 387
JO - Autoimmunity
JF - Autoimmunity
SN - 0891-6934
IS - 6-7
ER -