Animal models of Graves' hyperthyroidism

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An animal model of Graves' disease (GD) will help us to clearly understand the role of thyroid-stimulating hormone receptor (TSHR)-specific T cells and TSHR-Abs during the development of GD and to develop TSHR-specific immunotherapy. This review focuses on four different recent approaches towards the development of an animal model of GD. These approaches are: (1) Immunization of AKR/N mice with fibroblasts coexpressing syngeneic major histocompatibility complex (MHC) class II and TSHR. (2) Immunization of selected strains of mice with an expression vector containing TSHR cDNA. (3) Immunization of BALB/c mice with syngeneic M12 cells or xenogenic HEK-293 cells expressing full-length or extracellular domain of TSHR (ETSHR). (4) Injection of adenovirus-expressing TSHR into BALB/c mice.

Original languageEnglish
Pages (from-to)381-387
Number of pages7
JournalAutoimmunity
Volume36
Issue number6-7
DOIs
StatePublished - Sep 2003

Fingerprint

Thyrotropin Receptors
Hyperthyroidism
Animal Models
Graves Disease
Immunization
Inbred AKR Mouse
HEK293 Cells
Major Histocompatibility Complex
Adenoviridae
Immunotherapy
Complementary DNA
Fibroblasts
T-Lymphocytes
Injections

Keywords

  • Animal model
  • Graves' disease
  • Hyperthyroidism
  • TSHR autoantibodies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Animal models of Graves' hyperthyroidism. / Seetharamaiah, Gattadahalli.

In: Autoimmunity, Vol. 36, No. 6-7, 09.2003, p. 381-387.

Research output: Contribution to journalArticle

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