Bisphosphonates have been extensively studied with hundreds of studies describing how they affect various skeletal parameters using animal models. Despite this extensive body of literature, when the clinical description of osteonecrosis of the jaw emerged in 2003/2004, the relative paucity of data describing how bisphosphonates affect the maxillofacial skeletal became clear. Over the past 10 years, there have been several dozen publications showing various aspects of ONJ in mice, rats, dogs, and swine treated with bisphosphonates. Recent work has extended these fi ndings to treatment with RANK-L inhibitors. The establishment of these models will be essential in propelling the fi eld forward to understand the underlying pathophysiology of ONJ and ultimately fi nding a way to prevent or cure this debilitating condition.
|Original language||English (US)|
|Title of host publication||Medication-Related Osteonecrosis of the Jaws: Bisphosphonates, Denosumab, and New Agents|
|Publisher||Springer Berlin Heidelberg|
|Number of pages||13|
|ISBN (Print)||9783662437339, 9783662437322|
|State||Published - Jan 1 2015|
ASJC Scopus subject areas