Animal models of medication- related osteonecrosis of the jaw

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Bisphosphonates have been extensively studied with hundreds of studies describing how they affect various skeletal parameters using animal models. Despite this extensive body of literature, when the clinical description of osteonecrosis of the jaw emerged in 2003/2004, the relative paucity of data describing how bisphosphonates affect the maxillofacial skeletal became clear. Over the past 10 years, there have been several dozen publications showing various aspects of ONJ in mice, rats, dogs, and swine treated with bisphosphonates. Recent work has extended these fi ndings to treatment with RANK-L inhibitors. The establishment of these models will be essential in propelling the fi eld forward to understand the underlying pathophysiology of ONJ and ultimately fi nding a way to prevent or cure this debilitating condition.

Original languageEnglish (US)
Title of host publicationMedication-Related Osteonecrosis of the Jaws: Bisphosphonates, Denosumab, and New Agents
PublisherSpringer Berlin Heidelberg
Pages155-167
Number of pages13
ISBN (Print)9783662437339, 9783662437322
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

Fingerprint Dive into the research topics of 'Animal models of medication- related osteonecrosis of the jaw'. Together they form a unique fingerprint.

  • Cite this

    Allen, M. (2015). Animal models of medication- related osteonecrosis of the jaw. In Medication-Related Osteonecrosis of the Jaws: Bisphosphonates, Denosumab, and New Agents (pp. 155-167). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-43733-9_15