Animal models of myocardial and vascular injury

Aaron M. Abarbanell, Jeremy L. Herrmann, Brent R. Weil, Yue Wang, Jiangning Tan, Steven P. Moberly, Jeremy W. Fiege, Daniel R. Meldrum

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Over the past century, numerous animal models have been developed in an attempt to understand myocardial and vascular injury. However, the successful translation of results observed in animals to human therapy remains low. To understand this problem, we present several animal models of cardiac and vascular injury that are of particular relevance to the cardiac or vascular surgeon. We also explore the potential clinical implications and limitations of each model with respect to the human disease state. Our results underscore the concept that animal research requires an in-depth understanding of the model, animal physiology, and the potential confounding factors. Future outcome analyses with standardized animal models may improve translation of animal research from the bench to the bedside.

Original languageEnglish
Pages (from-to)239-249
Number of pages11
JournalJournal of Surgical Research
Volume162
Issue number2
DOIs
StatePublished - Aug 2010

Fingerprint

Vascular System Injuries
Animal Models
Blood Vessels
Therapeutics

Keywords

  • Animal models
  • Atherosclerosis
  • Comparative physiology
  • Endothelial damage
  • Heart failure
  • Ischemia/reperfusion
  • Myocardial infarction

ASJC Scopus subject areas

  • Surgery

Cite this

Abarbanell, A. M., Herrmann, J. L., Weil, B. R., Wang, Y., Tan, J., Moberly, S. P., ... Meldrum, D. R. (2010). Animal models of myocardial and vascular injury. Journal of Surgical Research, 162(2), 239-249. https://doi.org/10.1016/j.jss.2009.06.021

Animal models of myocardial and vascular injury. / Abarbanell, Aaron M.; Herrmann, Jeremy L.; Weil, Brent R.; Wang, Yue; Tan, Jiangning; Moberly, Steven P.; Fiege, Jeremy W.; Meldrum, Daniel R.

In: Journal of Surgical Research, Vol. 162, No. 2, 08.2010, p. 239-249.

Research output: Contribution to journalArticle

Abarbanell, AM, Herrmann, JL, Weil, BR, Wang, Y, Tan, J, Moberly, SP, Fiege, JW & Meldrum, DR 2010, 'Animal models of myocardial and vascular injury', Journal of Surgical Research, vol. 162, no. 2, pp. 239-249. https://doi.org/10.1016/j.jss.2009.06.021
Abarbanell AM, Herrmann JL, Weil BR, Wang Y, Tan J, Moberly SP et al. Animal models of myocardial and vascular injury. Journal of Surgical Research. 2010 Aug;162(2):239-249. https://doi.org/10.1016/j.jss.2009.06.021
Abarbanell, Aaron M. ; Herrmann, Jeremy L. ; Weil, Brent R. ; Wang, Yue ; Tan, Jiangning ; Moberly, Steven P. ; Fiege, Jeremy W. ; Meldrum, Daniel R. / Animal models of myocardial and vascular injury. In: Journal of Surgical Research. 2010 ; Vol. 162, No. 2. pp. 239-249.
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