Animal models of myocardial and vascular injury

Aaron M. Abarbanell, Jeremy L. Herrmann, Brent R. Weil, Yue Wang, Jiangning Tan, Steven P. Moberly, Jeremy W. Fiege, Daniel R. Meldrum

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Over the past century, numerous animal models have been developed in an attempt to understand myocardial and vascular injury. However, the successful translation of results observed in animals to human therapy remains low. To understand this problem, we present several animal models of cardiac and vascular injury that are of particular relevance to the cardiac or vascular surgeon. We also explore the potential clinical implications and limitations of each model with respect to the human disease state. Our results underscore the concept that animal research requires an in-depth understanding of the model, animal physiology, and the potential confounding factors. Future outcome analyses with standardized animal models may improve translation of animal research from the bench to the bedside.

Original languageEnglish (US)
Pages (from-to)239-249
Number of pages11
JournalJournal of Surgical Research
Volume162
Issue number2
DOIs
StatePublished - Aug 2010

Keywords

  • Animal models
  • Atherosclerosis
  • Comparative physiology
  • Endothelial damage
  • Heart failure
  • Ischemia/reperfusion
  • Myocardial infarction

ASJC Scopus subject areas

  • Surgery

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  • Cite this

    Abarbanell, A. M., Herrmann, J. L., Weil, B. R., Wang, Y., Tan, J., Moberly, S. P., Fiege, J. W., & Meldrum, D. R. (2010). Animal models of myocardial and vascular injury. Journal of Surgical Research, 162(2), 239-249. https://doi.org/10.1016/j.jss.2009.06.021