Animal models of osteonecrosis

Lynne C. Jones, Matthew Allen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Osteonecrosis is an uncommon but significant musculoskeletal disease characterized by focal areas of dead bone that often fail to heal even with intervention and has the potential to negatively impact a patient's quality of life. The knee and hip seem to be most susceptible to osteonecrosis although certain conditions, such as bisphosphonate treatment, have been associated with the development of osteonecrosis that is confined to the jaw. For most types of osteonecrosis, there remains much to be learned about either the pathophysiology of disease or the best course of treatment-questions that are best approached using an animal model. The different etiologies of the subclasses of osteonecrosis have led to a diverse number of animal models within the field. While no one animal model completely simulates all aspects of a particular type of osteonecrosis, models do exist that mimic various clinical aspects of osteonecrosis. This review discusses aspects of the common and novel animal models used to study juvenile osteonecrosis (Legg-Calvé-Perthes), trauma-induced osteonecrosis, alcohol- and corticosteroid-induced osteonecrosis, and osteonecrosis of the jaw associated with anti-remodeling drug treatment.

Original languageEnglish
Pages (from-to)63-80
Number of pages18
JournalClinical Reviews in Bone and Mineral Metabolism
Volume9
Issue number1
DOIs
StatePublished - Mar 2011

Fingerprint

Osteonecrosis
Animal Models
Jaw
Musculoskeletal Diseases
Diphosphonates
Hip
Knee
Adrenal Cortex Hormones
Therapeutics
Alcohols
Quality of Life

Keywords

  • Animal models
  • Corticosteroids
  • Legg-Calve-Perthes disease
  • ONJ
  • Osteonecrosis
  • Osteonecrosis of the jaw

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

Cite this

Animal models of osteonecrosis. / Jones, Lynne C.; Allen, Matthew.

In: Clinical Reviews in Bone and Mineral Metabolism, Vol. 9, No. 1, 03.2011, p. 63-80.

Research output: Contribution to journalArticle

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