Animal welfare act. Implication and predictions in lower vertebrate research

Kenneth R. Olson, Richard L. Crawford, William H. Gingerich, Roger D. Meyerhoff, John G. Miller

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The use of animals in basic and applied research is governed by both scientific objectives and ethical considerations. Heightened concern over the humane treatment of experimental animals by the scientific community and the public has led to the development of guidelines and regulations concerning animal care and use. Most of these regulations, to a large extent under the purview of the U.S Department of Agriculture (USDA) and federal granting agencies such as the National Institutes of Health (NII), are directed towards research on higher vertebrates, especially mammals. Guidelines for care and use of lower vertebrates are minimal to nonexistent and are frequently extrapolated from mammalian models. However, it appears that further regulation of lower vetebrate research is probable. This paper summarizes a panel discussion that was conducted the 14th ASTM Aquatic Toxicology Symposium on 22 April 1990. The panel consisted of two members from federal regulatory agencies (USDA and NIH) and three members from research institutions (representing industrial. Federal, and academic laboratories). The purpose of this discussion was to establish a dialogue on the care and use of lower vertebrates in research. Included is a discussion of the history and future of animal welfare legislation and how the various regulations are implemented in the three laboratory situations. Emphasis will be on fish, although the principles of animal care and use could apply to other ectotherms as well. A number of key issues need to be addressed by the scientific community relative to lower vertebrate research.

Original languageEnglish (US)
Title of host publicationASTM Special Technical Publication
PublisherPubl by ASTM
Number of pages7
ISBN (Print)0803114257
StatePublished - Dec 1 1991
Event14th Symposium on Aquatic Toxicology and Risk Assessment - San Francisco, CA, USA
Duration: Apr 22 1990Apr 24 1990

Publication series

NameASTM Special Technical Publication
ISSN (Print)0066-0558


Other14th Symposium on Aquatic Toxicology and Risk Assessment
CitySan Francisco, CA, USA

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Olson, K. R., Crawford, R. L., Gingerich, W. H., Meyerhoff, R. D., & Miller, J. G. (1991). Animal welfare act. Implication and predictions in lower vertebrate research. In ASTM Special Technical Publication (1124 ed., pp. 5-11). (ASTM Special Technical Publication; No. 1124). Publ by ASTM.