Anisometropia at Age 5 Years After Unilateral Intraocular Lens Implantation During Infancy in the Infant Aphakia Treatment Study

Infant Aphakia Treatment Study Group

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose To report the prevalence of anisometropia at age 5 years after unilateral intraocular lens (IOL) implantation in infants. Design Prospective randomized clinical trial. Methods Fifty-seven infants in the Infant Aphakia Treatment Study (IATS) with a unilateral cataract were randomized to IOL implantation with an initial targeted postoperative refractive error of either +8 diopters (D) (infants 28 to <48 days of age) or +6 D (infants 48–210 days of age). Anisometropia was calculated at age 5 years. Six patients were excluded from the analyses. Results Median age at cataract surgery was 2.2 months (interquartile range [IQR], 1.2, 3.5 months). The mean age at the age 5 years follow-up visit was 5.0 ± 0.1 years (range, 4.9–5.4 years). The median refractive error at the age 5 years visit of the treated eyes was −2.25 D (IQR −5.13, +0.88 D) and of the fellow eyes +1.50 D (IQR +0.88, +2.25). Median anisometropia was −3.50 D (IQR −8.25, −0.88 D); range −19.63 to +2.75 D. Patients with glaucoma in the treated eye (n = 9) had greater anisometropia (glaucoma, median −8.25 D; IQR −11.38, −5.25 D vs no glaucoma median −2.75; IQR −6.38, −0.75 D; P = .005). Conclusions The majority of pseudophakic eyes had significant anisometropia at age 5 years. Anisometropia was greater in patients that developed glaucoma. Variability in eye growth and myopic shift continue to make refractive outcomes challenging for IOL implantation during infancy.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalAmerican Journal of Ophthalmology
Volume180
DOIs
StatePublished - Aug 1 2017

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Anisometropia
Aphakia
Intraocular Lens Implantation
Glaucoma
Refractive Errors
Cataract
Therapeutics
Randomized Controlled Trials
Growth

ASJC Scopus subject areas

  • Ophthalmology

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Anisometropia at Age 5 Years After Unilateral Intraocular Lens Implantation During Infancy in the Infant Aphakia Treatment Study. / Infant Aphakia Treatment Study Group.

In: American Journal of Ophthalmology, Vol. 180, 01.08.2017, p. 1-7.

Research output: Contribution to journalArticle

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title = "Anisometropia at Age 5 Years After Unilateral Intraocular Lens Implantation During Infancy in the Infant Aphakia Treatment Study",
abstract = "Purpose To report the prevalence of anisometropia at age 5 years after unilateral intraocular lens (IOL) implantation in infants. Design Prospective randomized clinical trial. Methods Fifty-seven infants in the Infant Aphakia Treatment Study (IATS) with a unilateral cataract were randomized to IOL implantation with an initial targeted postoperative refractive error of either +8 diopters (D) (infants 28 to <48 days of age) or +6 D (infants 48–210 days of age). Anisometropia was calculated at age 5 years. Six patients were excluded from the analyses. Results Median age at cataract surgery was 2.2 months (interquartile range [IQR], 1.2, 3.5 months). The mean age at the age 5 years follow-up visit was 5.0 ± 0.1 years (range, 4.9–5.4 years). The median refractive error at the age 5 years visit of the treated eyes was −2.25 D (IQR −5.13, +0.88 D) and of the fellow eyes +1.50 D (IQR +0.88, +2.25). Median anisometropia was −3.50 D (IQR −8.25, −0.88 D); range −19.63 to +2.75 D. Patients with glaucoma in the treated eye (n = 9) had greater anisometropia (glaucoma, median −8.25 D; IQR −11.38, −5.25 D vs no glaucoma median −2.75; IQR −6.38, −0.75 D; P = .005). Conclusions The majority of pseudophakic eyes had significant anisometropia at age 5 years. Anisometropia was greater in patients that developed glaucoma. Variability in eye growth and myopic shift continue to make refractive outcomes challenging for IOL implantation during infancy.",
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AU - Lambert, Scott R.

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N2 - Purpose To report the prevalence of anisometropia at age 5 years after unilateral intraocular lens (IOL) implantation in infants. Design Prospective randomized clinical trial. Methods Fifty-seven infants in the Infant Aphakia Treatment Study (IATS) with a unilateral cataract were randomized to IOL implantation with an initial targeted postoperative refractive error of either +8 diopters (D) (infants 28 to <48 days of age) or +6 D (infants 48–210 days of age). Anisometropia was calculated at age 5 years. Six patients were excluded from the analyses. Results Median age at cataract surgery was 2.2 months (interquartile range [IQR], 1.2, 3.5 months). The mean age at the age 5 years follow-up visit was 5.0 ± 0.1 years (range, 4.9–5.4 years). The median refractive error at the age 5 years visit of the treated eyes was −2.25 D (IQR −5.13, +0.88 D) and of the fellow eyes +1.50 D (IQR +0.88, +2.25). Median anisometropia was −3.50 D (IQR −8.25, −0.88 D); range −19.63 to +2.75 D. Patients with glaucoma in the treated eye (n = 9) had greater anisometropia (glaucoma, median −8.25 D; IQR −11.38, −5.25 D vs no glaucoma median −2.75; IQR −6.38, −0.75 D; P = .005). Conclusions The majority of pseudophakic eyes had significant anisometropia at age 5 years. Anisometropia was greater in patients that developed glaucoma. Variability in eye growth and myopic shift continue to make refractive outcomes challenging for IOL implantation during infancy.

AB - Purpose To report the prevalence of anisometropia at age 5 years after unilateral intraocular lens (IOL) implantation in infants. Design Prospective randomized clinical trial. Methods Fifty-seven infants in the Infant Aphakia Treatment Study (IATS) with a unilateral cataract were randomized to IOL implantation with an initial targeted postoperative refractive error of either +8 diopters (D) (infants 28 to <48 days of age) or +6 D (infants 48–210 days of age). Anisometropia was calculated at age 5 years. Six patients were excluded from the analyses. Results Median age at cataract surgery was 2.2 months (interquartile range [IQR], 1.2, 3.5 months). The mean age at the age 5 years follow-up visit was 5.0 ± 0.1 years (range, 4.9–5.4 years). The median refractive error at the age 5 years visit of the treated eyes was −2.25 D (IQR −5.13, +0.88 D) and of the fellow eyes +1.50 D (IQR +0.88, +2.25). Median anisometropia was −3.50 D (IQR −8.25, −0.88 D); range −19.63 to +2.75 D. Patients with glaucoma in the treated eye (n = 9) had greater anisometropia (glaucoma, median −8.25 D; IQR −11.38, −5.25 D vs no glaucoma median −2.75; IQR −6.38, −0.75 D; P = .005). Conclusions The majority of pseudophakic eyes had significant anisometropia at age 5 years. Anisometropia was greater in patients that developed glaucoma. Variability in eye growth and myopic shift continue to make refractive outcomes challenging for IOL implantation during infancy.

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