Annexin 6 immunoreactivity in select cell populations in the rat brain

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We examined the distribution of annexin 6 (ANX6) in rat brain with immunohistochemistry (IHC). Several neuronal cell populations were intensely labeled with the ANX6 monoclonal antibody (MAb), including layer 5 of neocortex, the lateral septum, the lateral hypothalamic area, the red nucleus, and the Purkinje cell layer in cerebellum. Neuronal immunolabeling was localized to the nucleus and the cytosol. Darkly stained ANX6-immunoreactive glia, with the morphology characteristic of astrocytes, were abundant in the hippocampus, substantia nigra reticulata, and cerebellum. Evidence suggests that ANX6 may function in neuronal and glial calcium-dependent processes.

Original languageEnglish (US)
Pages (from-to)1277-1280
Number of pages4
JournalJournal of Histochemistry and Cytochemistry
Issue number9
StatePublished - Sep 2002


  • Basal forebrain
  • Calcium-binding protein
  • Cerebral cortex
  • Lateral hypothalamus
  • Radial glia

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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