Antagonistic interplay between mechanical forces and glucocorticoids in bone: A tale of kinases

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

The contrasting actions of mechanical forces and glucocorticoids (GC) on bone have been long recognized. However, the cellular and molecular mechanisms by which these stimuli impact the skeleton remain only partially known. Recent evidence gained from studies on bone cell apoptosis has revealed that mechanical forces and GC exhibit converse effects on osteocyte and osteoblast survival resulting from divergent actions on the focal adhesion kinases FAK and Pyk2, molecules that regulate integrin-dependent interactions between bone cells and the extracellular matrix (ECM). This prospect reviews these findings and poses the possibility that similar opposing effects on kinase signaling are responsible for other actions of mechanical forces and GC on the skeleton, in particular on bone formation and the Wnt signaling pathway.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Cellular Biochemistry
Volume111
Issue number1
DOIs
StatePublished - Sep 1 2010

Keywords

  • Bone formation
  • FAK
  • Glucocorticoids
  • Mechanical forces
  • Osteocytes
  • Pyk2
  • Wnt pathway

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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