Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment

Susan Koh, Marvin D. Nelson, Arzu Kovanlikaya, Lan S. Chen

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Intrathecal chemotherapy with methotrexate or cytosine arabinoside is the standard approach to prophylaxis and treatment of central nervous system leukemia in children. Progressive paraplegia, one of the devastating neurologic complications related to this mode of treatment, has been attributed to spinal cord toxicity. Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery. Gadolinium enhancement of anterior lumbosacral spinal nerve roots was demonstrated in all three patients, and an elevation of cerebrospinal fluid immunoglobulin G synthesis was evident in two patients with more severe symptoms. The clinical data suggest that anterior lumbosacral radiculopathy is also a type of neurologic complication associated with intrathecal methotrexate treatment. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)576-578
Number of pages3
JournalPediatric neurology
Issue number2
StatePublished - Aug 1999

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

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