Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment

Susan Koh, Marvin D. Nelson, Arzu Kovanlikaya, Lan Chen

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Intrathecal chemotherapy with methotrexate or cytosine arabinoside is the standard approach to prophylaxis and treatment of central nervous system leukemia in children. Progressive paraplegia, one of the devastating neurologic complications related to this mode of treatment, has been attributed to spinal cord toxicity. Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery. Gadolinium enhancement of anterior lumbosacral spinal nerve roots was demonstrated in all three patients, and an elevation of cerebrospinal fluid immunoglobulin G synthesis was evident in two patients with more severe symptoms. The clinical data suggest that anterior lumbosacral radiculopathy is also a type of neurologic complication associated with intrathecal methotrexate treatment. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)576-578
Number of pages3
JournalPediatric Neurology
Volume21
Issue number2
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Radiculopathy
Methotrexate
Nervous System
Paraparesis
Spinal Nerve Roots
Paraplegia
Cytarabine
Gadolinium
Cerebrospinal Fluid
Spinal Cord
Leukemia
Therapeutics
Central Nervous System
Immunoglobulin G
Drug Therapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment. / Koh, Susan; Nelson, Marvin D.; Kovanlikaya, Arzu; Chen, Lan.

In: Pediatric Neurology, Vol. 21, No. 2, 1999, p. 576-578.

Research output: Contribution to journalArticle

Koh, Susan ; Nelson, Marvin D. ; Kovanlikaya, Arzu ; Chen, Lan. / Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment. In: Pediatric Neurology. 1999 ; Vol. 21, No. 2. pp. 576-578.
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