Anti-desmoglein-1 antibodies in onchocerciasis, leishmaniasis and chagas disease suggest a possible etiological link to fogo selvagem

Luis A. Diaz, Luis A. Arteaga, Julio Hilario-Vargas, Jesus G. Valenzuela, Ning Li, Simon Warren, Valeria Aoki, Gunter Hans-Filho, Donald Eaton, Vandir Dos Santos, Thomas B. Nutman, Antonio Antunez De Mayolo, Bahjat F. Qaqish, Sebastiao A P Sampaio, Evandro A. Rivitti

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Pemphigus foliaceus (PF) and the endemic form Fogo Selvagem (FS) are mediated by pathogenic antibodies to the EC1-2 domains of desmoglein-1. There is a preclinical phase with antibodies to only EC5. Based on geographic clustering of cases, FS is thought to have an, as yet unidentified, environmental trigger. In this study we have searched for anti-desmoglein-1 antibodies in sera from parasitic (leishmaniasis, Chagas, and onchocerciasis), and infectious diseases (leprosy and South American (SA) blastomycosis), which are prevalent in the same geographic regions of Brazil as FS. A specific and sensitive desmoglein-1 ELISA detected antibodies in 34 of 41 onchocerciasis (83%), 38 of 88 leishmaniasis (43%), 18 of 31 Chagas disease (58%), 7 of 28 SA blastomycosis (25%), and 14 of 83 leprosy sera (17%). These sera recognized epitopes restricted to the EC5 domain. These findings identify several etiological factors for FS. It is hypothesized that a component of insect vector saliva, rather than the parasite itself may trigger an antibody response to EC-5. In persons with the known HLA susceptibility alleles and living in endemic areas, a response to the EC1-2 domains may subsequently develop by epitope spreading with associated clinical signs of FS.

Original languageEnglish (US)
Pages (from-to)1045-1051
Number of pages7
JournalJournal of Investigative Dermatology
Volume123
Issue number6
DOIs
StatePublished - Dec 2004
Externally publishedYes

Fingerprint

Desmoglein 1
Onchocerciasis
Leishmaniasis
Chagas Disease
Paracoccidioidomycosis
Antibodies
Leprosy
Epitopes
Serum
Insect Vectors
Saliva
Antibody Formation
Communicable Diseases
Brazil
Cluster Analysis
Parasites
Enzyme-Linked Immunosorbent Assay
Alleles

Keywords

  • Autoantibody
  • Chagas
  • Desmogleins
  • Etiology
  • Fogo selvagem
  • Leishmaniasis
  • Onchocerciasis
  • Pemphigus

ASJC Scopus subject areas

  • Dermatology

Cite this

Anti-desmoglein-1 antibodies in onchocerciasis, leishmaniasis and chagas disease suggest a possible etiological link to fogo selvagem. / Diaz, Luis A.; Arteaga, Luis A.; Hilario-Vargas, Julio; Valenzuela, Jesus G.; Li, Ning; Warren, Simon; Aoki, Valeria; Hans-Filho, Gunter; Eaton, Donald; Dos Santos, Vandir; Nutman, Thomas B.; De Mayolo, Antonio Antunez; Qaqish, Bahjat F.; Sampaio, Sebastiao A P; Rivitti, Evandro A.

In: Journal of Investigative Dermatology, Vol. 123, No. 6, 12.2004, p. 1045-1051.

Research output: Contribution to journalArticle

Diaz, LA, Arteaga, LA, Hilario-Vargas, J, Valenzuela, JG, Li, N, Warren, S, Aoki, V, Hans-Filho, G, Eaton, D, Dos Santos, V, Nutman, TB, De Mayolo, AA, Qaqish, BF, Sampaio, SAP & Rivitti, EA 2004, 'Anti-desmoglein-1 antibodies in onchocerciasis, leishmaniasis and chagas disease suggest a possible etiological link to fogo selvagem', Journal of Investigative Dermatology, vol. 123, no. 6, pp. 1045-1051. https://doi.org/10.1111/j.0022-202X.2004.23438.x
Diaz, Luis A. ; Arteaga, Luis A. ; Hilario-Vargas, Julio ; Valenzuela, Jesus G. ; Li, Ning ; Warren, Simon ; Aoki, Valeria ; Hans-Filho, Gunter ; Eaton, Donald ; Dos Santos, Vandir ; Nutman, Thomas B. ; De Mayolo, Antonio Antunez ; Qaqish, Bahjat F. ; Sampaio, Sebastiao A P ; Rivitti, Evandro A. / Anti-desmoglein-1 antibodies in onchocerciasis, leishmaniasis and chagas disease suggest a possible etiological link to fogo selvagem. In: Journal of Investigative Dermatology. 2004 ; Vol. 123, No. 6. pp. 1045-1051.
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abstract = "Pemphigus foliaceus (PF) and the endemic form Fogo Selvagem (FS) are mediated by pathogenic antibodies to the EC1-2 domains of desmoglein-1. There is a preclinical phase with antibodies to only EC5. Based on geographic clustering of cases, FS is thought to have an, as yet unidentified, environmental trigger. In this study we have searched for anti-desmoglein-1 antibodies in sera from parasitic (leishmaniasis, Chagas, and onchocerciasis), and infectious diseases (leprosy and South American (SA) blastomycosis), which are prevalent in the same geographic regions of Brazil as FS. A specific and sensitive desmoglein-1 ELISA detected antibodies in 34 of 41 onchocerciasis (83{\%}), 38 of 88 leishmaniasis (43{\%}), 18 of 31 Chagas disease (58{\%}), 7 of 28 SA blastomycosis (25{\%}), and 14 of 83 leprosy sera (17{\%}). These sera recognized epitopes restricted to the EC5 domain. These findings identify several etiological factors for FS. It is hypothesized that a component of insect vector saliva, rather than the parasite itself may trigger an antibody response to EC-5. In persons with the known HLA susceptibility alleles and living in endemic areas, a response to the EC1-2 domains may subsequently develop by epitope spreading with associated clinical signs of FS.",
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AU - Diaz, Luis A.

AU - Arteaga, Luis A.

AU - Hilario-Vargas, Julio

AU - Valenzuela, Jesus G.

AU - Li, Ning

AU - Warren, Simon

AU - Aoki, Valeria

AU - Hans-Filho, Gunter

AU - Eaton, Donald

AU - Dos Santos, Vandir

AU - Nutman, Thomas B.

AU - De Mayolo, Antonio Antunez

AU - Qaqish, Bahjat F.

AU - Sampaio, Sebastiao A P

AU - Rivitti, Evandro A.

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N2 - Pemphigus foliaceus (PF) and the endemic form Fogo Selvagem (FS) are mediated by pathogenic antibodies to the EC1-2 domains of desmoglein-1. There is a preclinical phase with antibodies to only EC5. Based on geographic clustering of cases, FS is thought to have an, as yet unidentified, environmental trigger. In this study we have searched for anti-desmoglein-1 antibodies in sera from parasitic (leishmaniasis, Chagas, and onchocerciasis), and infectious diseases (leprosy and South American (SA) blastomycosis), which are prevalent in the same geographic regions of Brazil as FS. A specific and sensitive desmoglein-1 ELISA detected antibodies in 34 of 41 onchocerciasis (83%), 38 of 88 leishmaniasis (43%), 18 of 31 Chagas disease (58%), 7 of 28 SA blastomycosis (25%), and 14 of 83 leprosy sera (17%). These sera recognized epitopes restricted to the EC5 domain. These findings identify several etiological factors for FS. It is hypothesized that a component of insect vector saliva, rather than the parasite itself may trigger an antibody response to EC-5. In persons with the known HLA susceptibility alleles and living in endemic areas, a response to the EC1-2 domains may subsequently develop by epitope spreading with associated clinical signs of FS.

AB - Pemphigus foliaceus (PF) and the endemic form Fogo Selvagem (FS) are mediated by pathogenic antibodies to the EC1-2 domains of desmoglein-1. There is a preclinical phase with antibodies to only EC5. Based on geographic clustering of cases, FS is thought to have an, as yet unidentified, environmental trigger. In this study we have searched for anti-desmoglein-1 antibodies in sera from parasitic (leishmaniasis, Chagas, and onchocerciasis), and infectious diseases (leprosy and South American (SA) blastomycosis), which are prevalent in the same geographic regions of Brazil as FS. A specific and sensitive desmoglein-1 ELISA detected antibodies in 34 of 41 onchocerciasis (83%), 38 of 88 leishmaniasis (43%), 18 of 31 Chagas disease (58%), 7 of 28 SA blastomycosis (25%), and 14 of 83 leprosy sera (17%). These sera recognized epitopes restricted to the EC5 domain. These findings identify several etiological factors for FS. It is hypothesized that a component of insect vector saliva, rather than the parasite itself may trigger an antibody response to EC-5. In persons with the known HLA susceptibility alleles and living in endemic areas, a response to the EC1-2 domains may subsequently develop by epitope spreading with associated clinical signs of FS.

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KW - Chagas

KW - Desmogleins

KW - Etiology

KW - Fogo selvagem

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KW - Onchocerciasis

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