Anti-erosive properties of solutions containing fluoride and different film-forming agents

Taís Scaramucci, Alessandra B. Borges, Frank Lippert, Domenick T. Zero, Idalina V. Aoki, Anderson T. Hara

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Objectives To evaluate the anti-erosive potential of solutions containing sodium fluoride (NaF, 225 ppm F) and different film-forming agents. Methods In Phase 1, hydroxyapatite crystals were pre-treated with solutions containing NaF (F), linear sodium polyphosphate (LPP), sodium pyrophosphate tetrabasic (PP), sodium tripolyphosphate (STP), sodium caseinate (SC), bovine serum albumin (BSA), stannous chloride (Sn) and some combinations thereof. Deionized water was the control (C). The pH-stat method was used to evaluate hydroxyapatite dissolution. In Phase 2, the most effective solutions were tested in two independent experiments. Both consisted of an erosion-remineralization cycling model using enamel and dentine specimens with three solution treatments per day. In Phase 2a, the challenge was performed with 0.3% citric acid (pH = 3.8). In Phase 2b, 1% citric acid (pH = 2.4) was used. Hard tissue surface loss was determined profilometrically. Data were analyzed with two-way ANOVA and Tukey tests. Results In Phase 1, F, LPP, Sn and some of their combinations caused the greatest reduction in hydroxyapatite dissolution. In Phase 2a, C showed the highest enamel loss, followed by LPP. There were no differences between all other groups. In Phase 2b: (F + LPP + Sn) < (F + LPP) = (F + Sn) < (F) = (LPP + Sn) < (LPP) < (Sn) < C. For dentine, in both experiments, only the fluoride-containing groups showed lower surface loss than C, except for LPP + Sn in 2a. Conclusions F, Sn, LPP reduced enamel erosion, this effect was enhanced by their combination under highly erosive conditions. For dentine, the F-containing groups showed similar protective effect. Clinical significance The addition of LPP and/or Sn can improve the fluoride solution protection against erosion of enamel but not of dentine.

Original languageEnglish (US)
Pages (from-to)458-465
Number of pages8
JournalJournal of Dentistry
Issue number4
StatePublished - Apr 1 2015


  • Dental erosion
  • Fluoride
  • Phosphate polymer
  • Protein
  • Stannous chloride

ASJC Scopus subject areas

  • Dentistry(all)

Fingerprint Dive into the research topics of 'Anti-erosive properties of solutions containing fluoride and different film-forming agents'. Together they form a unique fingerprint.

Cite this