Anti-Hu-associated paraneoplastic sensory neuronopathy responding to early aggressive immunotherapy

Report of two cases and review of literature

Shin J. Oh, Edward Dropcho, Gwen C. Claussen

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Anti-Hu-associated paraneoplastic sensory neuropathy (PSN) has been reported to be nonresponsive to immunotherapy or cancer therapy. We report 2 patients with anti-Hu-associated PSN who achieved sustained clinical improvement with early and aggressive immunotherapy 10-15 months before the diagnosis of small-cell lung carcinoma. Both had chronic 'sensory neuronopathy plus'; in addition to sensory neuronopathy, case 1 had a motor- autonomic dysfunction with encephalopathy, and case 2 had a motor-autonomic dysfunction with swallowing difficulty. These two cases were unusual in that sustained clinical improvement was achieved with early aggressive immunotherapy before the detection of cancer and without any concomitant anticancer therapy or lowering of anti-Hu antibody titer. We believe that early and aggressive immunotherapy should be tried in any patient with anti- Hu-associated PSN, as it may induce sustained clinical improvement.

Original languageEnglish
Pages (from-to)1576-1582
Number of pages7
JournalMuscle and Nerve
Volume20
Issue number12
DOIs
StatePublished - 1997

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Paraneoplastic Polyneuropathy
Immunotherapy
Small Cell Lung Carcinoma
Brain Diseases
Deglutition
Anti-Idiotypic Antibodies
Neoplasms
Therapeutics

Keywords

  • Anti-hu antibody
  • Immunotherapy
  • Paraneoplastic neuropathy
  • Paraneoplastic syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Anti-Hu-associated paraneoplastic sensory neuronopathy responding to early aggressive immunotherapy : Report of two cases and review of literature. / Oh, Shin J.; Dropcho, Edward; Claussen, Gwen C.

In: Muscle and Nerve, Vol. 20, No. 12, 1997, p. 1576-1582.

Research output: Contribution to journalArticle

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