Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction

A pilot study

Samir Gupta, Raymond M. Johnson, Kieren Mather, Matthias Clauss, Jalees Rehman, Chandan Saha, Zeruesenay Desta, Michael P. Dubé

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We performed a single-arm, open-label pilot trial of the anti-inflammatory drug pentoxifylline to reduce systemic inflammation and improve endothelial function, measured by flow-mediated dilation of the brachial artery, in HIV-infected patients not requiring antiretroviral therapy. Pentoxifylline significantly reduced circulating levels of vascular cell adhesion molecule-1 and interferon-gamma-induced protein and significantly improved endothelial function during the 8-week trial. Pentoxifylline may reverse HIV-related endothelial dysfunction by directly inhibiting the endothelial leukocyte adhesion pathway.

Original languageEnglish
Pages (from-to)1377-1380
Number of pages4
JournalAIDS
Volume24
Issue number9
DOIs
StatePublished - Jun 1 2010

Fingerprint

Pentoxifylline
Anti-Inflammatory Agents
HIV
Brachial Artery
Vascular Cell Adhesion Molecule-1
Interferon-gamma
Dilatation
Leukocytes
Therapeutics
Inflammation
Pharmaceutical Preparations
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction : A pilot study. / Gupta, Samir; Johnson, Raymond M.; Mather, Kieren; Clauss, Matthias; Rehman, Jalees; Saha, Chandan; Desta, Zeruesenay; Dubé, Michael P.

In: AIDS, Vol. 24, No. 9, 01.06.2010, p. 1377-1380.

Research output: Contribution to journalArticle

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