Angiogenesis plays a central role in both local tumor growth as well as distant metastasis in breast cancer (1). The inhibition of angiogenesis is an attractive therapeutic target, with the potential for widespread activity and low toxicity, as well as the potential for synergy with classic cytotoxic therapy and radiotherapy. In this chapter, we explore the role of angiogenesis in breast cancer and recent attempts to quantify angiogenesis and tumor vasculature. We also discuss clinical trial results, potential mechanisms of resistance, and the special challenges posed by the development of antiangiogenic agents.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)