Antibacterial therapy of neurosyphilis: Lack of impact of new therapies

Latisha Ali, Karen L. Roos

Research output: Contribution to journalReview article

19 Scopus citations


Neurosyphilis is caused by the spirochete Treponema pallidum. These organisms divide slowly, requiring long exposure to antibacterials for treatment success. In order for an antibacterial to be effective in the therapy of neurosyphilis, it must achieve treponemicidal concentrations in the CSF, have a long half-life and be given in a treatment regimen that favours compliance. Penicillin was first introduced for the treatment of syphilis in 1943, and despite interest in the use of amoxicillin, erythromycin, tetracycline, doxycycline, ceftriaxone and azithromycin, penicillin remains the only recommended antibacterial agent for neurosyphilis.

Original languageEnglish (US)
Pages (from-to)799-802
Number of pages4
JournalCNS Drugs
Issue number12
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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