Antibodies to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma

Shou Jiang Gao, Melissa Alsina, Jian Hong Deng, Chantal R. Harrison, Eduardo A. Montalvo, Charles T. Leach, G. David Roodman, Hal B. Jenson

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Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) serologic assays were used to detect specific antibodies to KSHV lytic and latent antigens in 27 patients with multiple myeloma, 27 control patients with other cancers, and 50 random blood donors. Antibodies to KSHV recombinant minor capsid antigen orf65 were found in 81% of patients with multiple myeloma, 22% of control patients with other cancers, and 6% of the blood donors. Antibodies to KSHV latent nuclear antigens were found in 52% of patients with multiple myeloma, 26% of control patients with other cancers, and 2% of the blood donors. All of the 11 patients with progressive multiple myeloma were KSHV-seropositive. Antibodies to Epstein-Barr virus nuclear antigen 1 were present in 89% of patients with multiple myeloma, 93% of control patients with other cancers, and 88% of the blood donors. These data support the possible association of KSHV infection with multiple myeloma, particularly with progressive disease.

Original languageEnglish (US)
Pages (from-to)846-849
Number of pages4
JournalJournal of Infectious Diseases
Volume178
Issue number3
StatePublished - 1998
Externally publishedYes

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Human Herpesvirus 8
Multiple Myeloma
Antibodies
Blood Donors
Neoplasms
Epstein-Barr Virus Nuclear Antigens
Antigens
Herpesviridae Infections
Capsid

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Gao, S. J., Alsina, M., Deng, J. H., Harrison, C. R., Montalvo, E. A., Leach, C. T., ... Jenson, H. B. (1998). Antibodies to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. Journal of Infectious Diseases, 178(3), 846-849.

Antibodies to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. / Gao, Shou Jiang; Alsina, Melissa; Deng, Jian Hong; Harrison, Chantal R.; Montalvo, Eduardo A.; Leach, Charles T.; Roodman, G. David; Jenson, Hal B.

In: Journal of Infectious Diseases, Vol. 178, No. 3, 1998, p. 846-849.

Research output: Contribution to journalArticle

Gao, SJ, Alsina, M, Deng, JH, Harrison, CR, Montalvo, EA, Leach, CT, Roodman, GD & Jenson, HB 1998, 'Antibodies to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma', Journal of Infectious Diseases, vol. 178, no. 3, pp. 846-849.
Gao SJ, Alsina M, Deng JH, Harrison CR, Montalvo EA, Leach CT et al. Antibodies to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. Journal of Infectious Diseases. 1998;178(3):846-849.
Gao, Shou Jiang ; Alsina, Melissa ; Deng, Jian Hong ; Harrison, Chantal R. ; Montalvo, Eduardo A. ; Leach, Charles T. ; Roodman, G. David ; Jenson, Hal B. / Antibodies to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. In: Journal of Infectious Diseases. 1998 ; Vol. 178, No. 3. pp. 846-849.
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