Anticaries Potential of a Sodium Monofluorophosphate Dentifrice Containing Calcium Sodium Phosphosilicate: Exploratory in situ Randomized Trial

Charles R. Parkinson, Muhammad Siddiqi, Stephen Mason, Frank Lippert, Anderson Hara, Domenick Zero

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Calcium sodium phosphosilicate (CSPS) is a bioactive glass material that alleviates dentin hypersensitivity and is postulated to confer remineralization of caries lesions. This single-centre, randomized, single (investigator)-blind, placebo-controlled, crossover, in situ study explored whether the addition of 5% CSPS to a nonaqueous fluoride (F) such as sodium monofluorophosphate (SMFP)-containing dentifrice affects its cariostatic ability. Seventy-seven subjects wore 4 gauze-covered enamel specimens with preformed lesions (2 surface-softened and 2 subsurface) placed buccally on their mandibular bilateral dentures for up to 4 weeks. Subjects brushed twice daily with 1 of the 5 study dentifrices: 927 ppm F/5% CSPS, 927 ppm F/0% CSPS, 250 ppm F/0% CSPS, 0 ppm F/5% CSPS, or 0 ppm F/0% CSPS. Specimens were retrieved after either 21 (surface-softened lesions; analyzed by Knoop surface microhardness [SMH]) or 28 days (subsurface lesions; analyzed by transverse microradiography). The enamel fluoride uptake was determined for all specimens using a microbiopsy technique. The concentrations of fluoride and calcium in gauze-retrieved plaque were also evaluated. Higher dentifrice fluoride concentrations led to greater remineralization and fluoridation of both lesion types and increased plaque fluoride concentrations. CSPS did not improve the cariostatic properties of SMFP; there were no statistically significant differences between 927 ppm F/5% CSPS and 927 ppm F/0% CSPS in percent SMH recovery = 0.6788), change in integrated mineral loss (= 0.5908), or lesion depth (= 0.6622). Likewise, 0 ppm F/5% CSPS did not provide any benefits in comparison to 0 ppm F/0% CSPS. In conclusion, CSPS does not negatively impact nor does it improve the ability of an SMFP dentifrice to affect remineralization of caries lesions.

Original languageEnglish (US)
Pages (from-to)170-178
Number of pages9
JournalCaries Research
Volume51
Issue number2
DOIs
StatePublished - Mar 1 2017

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fluorophosphate
Dentifrices
Sodium
Calcium
Fluorides
Dental Enamel
Dentin Sensitivity
Calcium Fluoride
Microradiography

Keywords

  • Calcium sodium phosphosilicate
  • Caries
  • Dentifrice
  • Fluoride
  • In situ model
  • NovaMin®

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Anticaries Potential of a Sodium Monofluorophosphate Dentifrice Containing Calcium Sodium Phosphosilicate : Exploratory in situ Randomized Trial. / Parkinson, Charles R.; Siddiqi, Muhammad; Mason, Stephen; Lippert, Frank; Hara, Anderson; Zero, Domenick.

In: Caries Research, Vol. 51, No. 2, 01.03.2017, p. 170-178.

Research output: Contribution to journalArticle

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title = "Anticaries Potential of a Sodium Monofluorophosphate Dentifrice Containing Calcium Sodium Phosphosilicate: Exploratory in situ Randomized Trial",
abstract = "Calcium sodium phosphosilicate (CSPS) is a bioactive glass material that alleviates dentin hypersensitivity and is postulated to confer remineralization of caries lesions. This single-centre, randomized, single (investigator)-blind, placebo-controlled, crossover, in situ study explored whether the addition of 5{\%} CSPS to a nonaqueous fluoride (F) such as sodium monofluorophosphate (SMFP)-containing dentifrice affects its cariostatic ability. Seventy-seven subjects wore 4 gauze-covered enamel specimens with preformed lesions (2 surface-softened and 2 subsurface) placed buccally on their mandibular bilateral dentures for up to 4 weeks. Subjects brushed twice daily with 1 of the 5 study dentifrices: 927 ppm F/5{\%} CSPS, 927 ppm F/0{\%} CSPS, 250 ppm F/0{\%} CSPS, 0 ppm F/5{\%} CSPS, or 0 ppm F/0{\%} CSPS. Specimens were retrieved after either 21 (surface-softened lesions; analyzed by Knoop surface microhardness [SMH]) or 28 days (subsurface lesions; analyzed by transverse microradiography). The enamel fluoride uptake was determined for all specimens using a microbiopsy technique. The concentrations of fluoride and calcium in gauze-retrieved plaque were also evaluated. Higher dentifrice fluoride concentrations led to greater remineralization and fluoridation of both lesion types and increased plaque fluoride concentrations. CSPS did not improve the cariostatic properties of SMFP; there were no statistically significant differences between 927 ppm F/5{\%} CSPS and 927 ppm F/0{\%} CSPS in percent SMH recovery = 0.6788), change in integrated mineral loss (= 0.5908), or lesion depth (= 0.6622). Likewise, 0 ppm F/5{\%} CSPS did not provide any benefits in comparison to 0 ppm F/0{\%} CSPS. In conclusion, CSPS does not negatively impact nor does it improve the ability of an SMFP dentifrice to affect remineralization of caries lesions.",
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