Antigenic determinants in amyloid deposits

E. S. Cathcart, M. S. Skinner, A. S. Cohen, O. J. Lawless, Merrill Benson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

PRECISE analyses of human amyloid laden tissues have shown that they contain at least two specific components - a fibrillar protein of uniform cross-sectional diameter1,2 and a rod-shaped protein (P-component). Units of the latter look pentagonal under the electron microscope and show antigenic identity with an α-globulin present in human plasma 3-5. Preliminary studies have also suggested that the fibrillar component of amyloid is non-immunogenic whereas the P-component is capable of eliciting a strong antibody response6-8. Recently, we have succeeded in preparing antisera not only to the P-component but also to alkali degraded amyloid fibrils (DAM), according to the method of Pras et al.9. Here we show that these antisera react not only with DAM but also with amyloid deposits in various tissues, particularly liver, spleen and kidney. Data are also presented which compare the tissue reactivity of anti-DAM and anti-P-component antisera measured by the fluorescent antibody technique.

Original languageEnglish (US)
Pages (from-to)1090-1091
Number of pages2
JournalNature
Volume228
Issue number5276
DOIs
StatePublished - 1970
Externally publishedYes

Fingerprint

Amyloid Plaques
Amyloid
Epitopes
Immune Sera
Globulins
Alkalies
Fluorescent Antibody Technique
Proteins
Spleen
Electrons
Kidney
Antibodies
Liver

ASJC Scopus subject areas

  • General

Cite this

Cathcart, E. S., Skinner, M. S., Cohen, A. S., Lawless, O. J., & Benson, M. (1970). Antigenic determinants in amyloid deposits. Nature, 228(5276), 1090-1091. https://doi.org/10.1038/2281090b0

Antigenic determinants in amyloid deposits. / Cathcart, E. S.; Skinner, M. S.; Cohen, A. S.; Lawless, O. J.; Benson, Merrill.

In: Nature, Vol. 228, No. 5276, 1970, p. 1090-1091.

Research output: Contribution to journalArticle

Cathcart, ES, Skinner, MS, Cohen, AS, Lawless, OJ & Benson, M 1970, 'Antigenic determinants in amyloid deposits', Nature, vol. 228, no. 5276, pp. 1090-1091. https://doi.org/10.1038/2281090b0
Cathcart ES, Skinner MS, Cohen AS, Lawless OJ, Benson M. Antigenic determinants in amyloid deposits. Nature. 1970;228(5276):1090-1091. https://doi.org/10.1038/2281090b0
Cathcart, E. S. ; Skinner, M. S. ; Cohen, A. S. ; Lawless, O. J. ; Benson, Merrill. / Antigenic determinants in amyloid deposits. In: Nature. 1970 ; Vol. 228, No. 5276. pp. 1090-1091.
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