Antigenic stimulation and the occurrence of chronic lymphocytic leukemia

Karin A. Rosenblatt, Thomas D. Koepsell, Janet R. Daling, Joseph L. Lyon, G. Marie Swanson, Raymond S. Greenberg, Noel S. Weiss

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    Data from a population-based case-control study of chronic lymphocytic leukemia were analyzed to assess the possible etiologic role of chronic antigenic stimulation. The study, conducted in four geographic areas of the United States (the metropolitan areas surrounding Seattle, Washington, Salt Lake City, Utah, Detroit, Michigan, and Atlanta, Georgia) sought to identify all incident cases (n = 430) among residents diagnosed between July 1, 1977 and December 31, 1981. The responses of these cases to questions about possible sources of antigenic stimulation were compared with the responses of controls selected from the populations of these areas. Little difference between cases and controls was present for a history of most forms of viral and bacterial infection and for a history of allergies or allergy treatment. However, a relation was observed with antecedent syphilis infection (odds ratio (OR) = 5.0, 95% confidence interval (Cl) 2.0-12.9). Associations of smaller magnitude were observed with a history of tuberculosis (OR = 1.9, 95% Cl 1.0-3.7) and of urinary tract infection (OR = 1.4, 95% Cl 1.1-1.9). Overall, however, the authors found little evidence of a relation between chronic antigenic stimulation and the occurrence of chronic lymphocytic leukemia. Nonetheless, because the measure of prior antigenic stimulation was restricted to that obtained through interviews and undoubtedly was an insensitive one, these negative results should not be interpreted as ruling out antigenic stimulation as a possible cause of some cases of chronic lymphocytic leukemia. Am J Epidemiol 1991; 134: 22-8.

    Original languageEnglish (US)
    Pages (from-to)22-28
    Number of pages7
    JournalAmerican journal of epidemiology
    Issue number1
    StatePublished - Jul 1 1991


    • Communicable diseases
    • Leukemia
    • Lymphocytic

    ASJC Scopus subject areas

    • Epidemiology

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    Rosenblatt, K. A., Koepsell, T. D., Daling, J. R., Lyon, J. L., Swanson, G. M., Greenberg, R. S., & Weiss, N. S. (1991). Antigenic stimulation and the occurrence of chronic lymphocytic leukemia. American journal of epidemiology, 134(1), 22-28.