Antigenic stimulation and thj occurrence of multiple myeloma

Thomas D. Koepsell, Janet R. Daling, Noel S. Weiss, John W. Taylor, Andrew F. Olshan, Joseph L. Lyon, G. Marie Swanson, Margaret Child

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

To evaluate whether potent or prolonged stimulation of the immune system increases the risk of multiple myeloma, the authors compared 698 myeloma cases which occurred between July 1, 1977 and June 30, 1981 in four geographic areas of the United States with 1,683 demographically similar controls from the same areas. Cases and controls were interviewed about past exposures which may have involved antigenlc challenge. Although few positive associations emerged, those most consistent with the immune stimulation hypothesis were modest associations between myeloma and a history of rheumatic fever (relative risk (RR) = 1.74,95% confidence interval (Cl) = 1.09-2.77) and between myeloma and urinary tract infection (HR = 1.30, 95% Cl = 1.00-1.69, when self-respondent cases were compared with controls). Little association was found between the risk of myeloma and the number of past viral Illnesses, number of bacterial illnesses, or number of allergy desensitization injections. Myeloma risk was found to be Inversely related to the number of diseases against which a subject reported having been immunized, perhaps because of differences in socioeconomic status between cases and controls. These findings provide little support for the immune system stimulation hypothesis of myeloma etiology, but because of the limitations of Interview techniques for assessing antigen exposure, further studies using laboratory methods may be warranted.

Original languageEnglish (US)
Pages (from-to)1051-1062
Number of pages12
JournalAmerican Journal of Epidemiology
Volume126
Issue number6
StatePublished - Dec 1987
Externally publishedYes

Fingerprint

Multiple Myeloma
Immune System
Rheumatic Fever
Urinary Tract Infections
Social Class
Hypersensitivity
Confidence Intervals
Interviews
Antigens
Injections

Keywords

  • Immune system
  • Multiple myeiorna

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Cite this

Koepsell, T. D., Daling, J. R., Weiss, N. S., Taylor, J. W., Olshan, A. F., Lyon, J. L., ... Child, M. (1987). Antigenic stimulation and thj occurrence of multiple myeloma. American Journal of Epidemiology, 126(6), 1051-1062.

Antigenic stimulation and thj occurrence of multiple myeloma. / Koepsell, Thomas D.; Daling, Janet R.; Weiss, Noel S.; Taylor, John W.; Olshan, Andrew F.; Lyon, Joseph L.; Swanson, G. Marie; Child, Margaret.

In: American Journal of Epidemiology, Vol. 126, No. 6, 12.1987, p. 1051-1062.

Research output: Contribution to journalArticle

Koepsell, TD, Daling, JR, Weiss, NS, Taylor, JW, Olshan, AF, Lyon, JL, Swanson, GM & Child, M 1987, 'Antigenic stimulation and thj occurrence of multiple myeloma', American Journal of Epidemiology, vol. 126, no. 6, pp. 1051-1062.
Koepsell TD, Daling JR, Weiss NS, Taylor JW, Olshan AF, Lyon JL et al. Antigenic stimulation and thj occurrence of multiple myeloma. American Journal of Epidemiology. 1987 Dec;126(6):1051-1062.
Koepsell, Thomas D. ; Daling, Janet R. ; Weiss, Noel S. ; Taylor, John W. ; Olshan, Andrew F. ; Lyon, Joseph L. ; Swanson, G. Marie ; Child, Margaret. / Antigenic stimulation and thj occurrence of multiple myeloma. In: American Journal of Epidemiology. 1987 ; Vol. 126, No. 6. pp. 1051-1062.
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