Antiinflammatory activity of the platelet-activating factor receptor antagonist A-85783

Jeffrey Travers, Y. Pei, S. M. Morin, A. F. Hood

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Accumulating evidence suggests an important role for the lipid mediator, platelet-activating factor (PAF), in cutaneous inflammation. In these studies the antiinflammatory effects of the potent and selective lipophilic PAF receptor antagonist A-85783 topically applied to the ventral ears of male Wistar rats were assessed. Intradermal injections of PAF into rat ears resulted in cutaneous inflammation as assessed by both ear thickness measurements and histological evaluation. Pretreatment of the ears with A-85783 resulted in an inhibition of subsequent PAF-induced inflammation. A-85783 treatment also inhibited phorbol myristic acetate-induced cutaneous inflammation, suggesting that the PAF receptor is involved in the etiology of this experimental dermatitis. These findings demonstrate that epicutaneous A-85783 is an appropriate tool to study the role of the PAF receptor in cutaneous inflammation, and suggest the possible clinical utility of this new class of antiinflammatory agents.

Original languageEnglish
Pages (from-to)569-573
Number of pages5
JournalArchives of Dermatological Research
Volume290
Issue number10
DOIs
StatePublished - 1998

Fingerprint

A 85783.0
Anti-Inflammatory Agents
Ear
Platelet Activating Factor
Inflammation
Skin
Intradermal Injections
Dermatitis
Wistar Rats
Acetates
platelet activating factor receptor
Lipids

Keywords

  • Dermatitis
  • Phorbol myristic acetate
  • Platelet-activating factor
  • Platelet-activating factor receptor
  • Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

Antiinflammatory activity of the platelet-activating factor receptor antagonist A-85783. / Travers, Jeffrey; Pei, Y.; Morin, S. M.; Hood, A. F.

In: Archives of Dermatological Research, Vol. 290, No. 10, 1998, p. 569-573.

Research output: Contribution to journalArticle

@article{9cc3fa836b8e469da5f379faef221dec,
title = "Antiinflammatory activity of the platelet-activating factor receptor antagonist A-85783",
abstract = "Accumulating evidence suggests an important role for the lipid mediator, platelet-activating factor (PAF), in cutaneous inflammation. In these studies the antiinflammatory effects of the potent and selective lipophilic PAF receptor antagonist A-85783 topically applied to the ventral ears of male Wistar rats were assessed. Intradermal injections of PAF into rat ears resulted in cutaneous inflammation as assessed by both ear thickness measurements and histological evaluation. Pretreatment of the ears with A-85783 resulted in an inhibition of subsequent PAF-induced inflammation. A-85783 treatment also inhibited phorbol myristic acetate-induced cutaneous inflammation, suggesting that the PAF receptor is involved in the etiology of this experimental dermatitis. These findings demonstrate that epicutaneous A-85783 is an appropriate tool to study the role of the PAF receptor in cutaneous inflammation, and suggest the possible clinical utility of this new class of antiinflammatory agents.",
keywords = "Dermatitis, Phorbol myristic acetate, Platelet-activating factor, Platelet-activating factor receptor, Skin",
author = "Jeffrey Travers and Y. Pei and Morin, {S. M.} and Hood, {A. F.}",
year = "1998",
doi = "10.1007/s004030050353",
language = "English",
volume = "290",
pages = "569--573",
journal = "Archives of Dermatological Research",
issn = "0340-3696",
publisher = "Springer Verlag",
number = "10",

}

TY - JOUR

T1 - Antiinflammatory activity of the platelet-activating factor receptor antagonist A-85783

AU - Travers, Jeffrey

AU - Pei, Y.

AU - Morin, S. M.

AU - Hood, A. F.

PY - 1998

Y1 - 1998

N2 - Accumulating evidence suggests an important role for the lipid mediator, platelet-activating factor (PAF), in cutaneous inflammation. In these studies the antiinflammatory effects of the potent and selective lipophilic PAF receptor antagonist A-85783 topically applied to the ventral ears of male Wistar rats were assessed. Intradermal injections of PAF into rat ears resulted in cutaneous inflammation as assessed by both ear thickness measurements and histological evaluation. Pretreatment of the ears with A-85783 resulted in an inhibition of subsequent PAF-induced inflammation. A-85783 treatment also inhibited phorbol myristic acetate-induced cutaneous inflammation, suggesting that the PAF receptor is involved in the etiology of this experimental dermatitis. These findings demonstrate that epicutaneous A-85783 is an appropriate tool to study the role of the PAF receptor in cutaneous inflammation, and suggest the possible clinical utility of this new class of antiinflammatory agents.

AB - Accumulating evidence suggests an important role for the lipid mediator, platelet-activating factor (PAF), in cutaneous inflammation. In these studies the antiinflammatory effects of the potent and selective lipophilic PAF receptor antagonist A-85783 topically applied to the ventral ears of male Wistar rats were assessed. Intradermal injections of PAF into rat ears resulted in cutaneous inflammation as assessed by both ear thickness measurements and histological evaluation. Pretreatment of the ears with A-85783 resulted in an inhibition of subsequent PAF-induced inflammation. A-85783 treatment also inhibited phorbol myristic acetate-induced cutaneous inflammation, suggesting that the PAF receptor is involved in the etiology of this experimental dermatitis. These findings demonstrate that epicutaneous A-85783 is an appropriate tool to study the role of the PAF receptor in cutaneous inflammation, and suggest the possible clinical utility of this new class of antiinflammatory agents.

KW - Dermatitis

KW - Phorbol myristic acetate

KW - Platelet-activating factor

KW - Platelet-activating factor receptor

KW - Skin

UR - http://www.scopus.com/inward/record.url?scp=0031725804&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031725804&partnerID=8YFLogxK

U2 - 10.1007/s004030050353

DO - 10.1007/s004030050353

M3 - Article

VL - 290

SP - 569

EP - 573

JO - Archives of Dermatological Research

JF - Archives of Dermatological Research

SN - 0340-3696

IS - 10

ER -