Antimicrotubule benzimidazoles inhibit in vitro growth of Pneumocystis carinii

M. S. Bartlett, T. D. Edlind, M. M. Durkin, M. M. Shaw, Sherry Queener, J. W. Smith

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Nine antimicrotubule benzimidazole derivatives tested in a Pneumocystis carinii culture system with human embryonic lung fibroblast monolayers inhibited organism proliferation. The concentrations of drugs inhibitory in culture ranged from 10 to 0.1 μg/ml, with thiabendazole being the least effective (10 μg/ml) and parbendazole being the most effective (0.1 μg/ml). The parent compound, benzimidazole, was inactive at 10 μg/ml. Demonstration that this group of compounds has activity against P. carinii provides a new potential target that can be exploited, the microtubules. Also, the variability in the effectiveness of the compounds provides the basis for studies of structure-activity relationships, which were initiated in this study.

Original languageEnglish
Pages (from-to)779-782
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume36
Issue number4
StatePublished - 1992

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Benzimidazoles
Pneumocystis carinii
Thiabendazole
Structure-Activity Relationship
Growth
Microtubules
Fibroblasts
Lung
Pharmaceutical Preparations
In Vitro Techniques
benzimidazole
parbendazole

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Bartlett, M. S., Edlind, T. D., Durkin, M. M., Shaw, M. M., Queener, S., & Smith, J. W. (1992). Antimicrotubule benzimidazoles inhibit in vitro growth of Pneumocystis carinii. Antimicrobial Agents and Chemotherapy, 36(4), 779-782.

Antimicrotubule benzimidazoles inhibit in vitro growth of Pneumocystis carinii. / Bartlett, M. S.; Edlind, T. D.; Durkin, M. M.; Shaw, M. M.; Queener, Sherry; Smith, J. W.

In: Antimicrobial Agents and Chemotherapy, Vol. 36, No. 4, 1992, p. 779-782.

Research output: Contribution to journalArticle

Bartlett, MS, Edlind, TD, Durkin, MM, Shaw, MM, Queener, S & Smith, JW 1992, 'Antimicrotubule benzimidazoles inhibit in vitro growth of Pneumocystis carinii', Antimicrobial Agents and Chemotherapy, vol. 36, no. 4, pp. 779-782.
Bartlett, M. S. ; Edlind, T. D. ; Durkin, M. M. ; Shaw, M. M. ; Queener, Sherry ; Smith, J. W. / Antimicrotubule benzimidazoles inhibit in vitro growth of Pneumocystis carinii. In: Antimicrobial Agents and Chemotherapy. 1992 ; Vol. 36, No. 4. pp. 779-782.
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