Antioxidant vitamin C prevents decline in endothelial function during sitting

Saurabh S. Thosar, Sylvanna L. Bielko, Chad S. Wiggins, James E. Klaunig, Kieren Mather, Janet P. Wallace

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: This study was designed to test the hypothesis that antioxidant Vitamin C prevents the impairment of endothelial function during prolonged sitting. Material/Methods: Eleven men (24.2±4.4 yrs) participated in 2 randomized 3-h sitting trials. In the sitting without vitamin C (SIT) and the sitting with vitamin C (VIT) trial, participants were seated for 3 h without moving their legs. Additionally, in the VIT trial, participants ingested 2 vitamin C tablets (1 g and 500 mg) at 30 min and 1 h 30 min, respectively. Superficial femoral artery (SFA) flow-mediated dilation (FMD) was measured hourly for 3 h. Results: By a 1-way ANOVA, there was a significant decline in FMD during 3 h of SIT (p<0.001). Simultaneously, there was a significant decline in antegrade (p=0.04) and mean (0.037) shear rates. For the SIT and VIT trials by a 2-way (trial x time) repeated measures ANOVA, there was a significant interaction (p=0.001). Pairwise testing revealed significant between-SFA FMD in the SIT and VIT trial at each hour after baseline, showing that VIT prevented the decline in FMD 1 h (p=0.009), 2 h (p=0.016), and 3 h (p=0.004). There was no difference in the shear rates between SIT and VIT trials (p>0.05). Conclusions: Three hours of sitting resulted in impaired SFA FMD. Antioxidant Vitamin C prevented the decline in SFA FMD, suggesting that oxidative stress may contribute to the impairment in endothelial function during sitting.

Original languageEnglish
Pages (from-to)1015-1021
Number of pages7
JournalMedical Science Monitor
Volume21
DOIs
StatePublished - Apr 7 2015

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Ascorbic Acid
Antioxidants
Dilatation
Femoral Artery
Tablets
Leg
Analysis of Variance
Oxidative Stress

Keywords

  • Antioxidants
  • Oxidative stress
  • Sedentary lifestyle

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Thosar, S. S., Bielko, S. L., Wiggins, C. S., Klaunig, J. E., Mather, K., & Wallace, J. P. (2015). Antioxidant vitamin C prevents decline in endothelial function during sitting. Medical Science Monitor, 21, 1015-1021. https://doi.org/10.12659/MSM.893192

Antioxidant vitamin C prevents decline in endothelial function during sitting. / Thosar, Saurabh S.; Bielko, Sylvanna L.; Wiggins, Chad S.; Klaunig, James E.; Mather, Kieren; Wallace, Janet P.

In: Medical Science Monitor, Vol. 21, 07.04.2015, p. 1015-1021.

Research output: Contribution to journalArticle

Thosar, SS, Bielko, SL, Wiggins, CS, Klaunig, JE, Mather, K & Wallace, JP 2015, 'Antioxidant vitamin C prevents decline in endothelial function during sitting', Medical Science Monitor, vol. 21, pp. 1015-1021. https://doi.org/10.12659/MSM.893192
Thosar, Saurabh S. ; Bielko, Sylvanna L. ; Wiggins, Chad S. ; Klaunig, James E. ; Mather, Kieren ; Wallace, Janet P. / Antioxidant vitamin C prevents decline in endothelial function during sitting. In: Medical Science Monitor. 2015 ; Vol. 21. pp. 1015-1021.
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