Antiphospholipid antibodies in blood and cerebrospinal fluids of patients with psychosis

Deborah K. Sokol, Roderick S. O'Brien, Dawn R. Wagenknecht, Thota Rao, John A. McIntyre

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Antiphospholipid antibodies (aPL) have been reported in the cerebrospinal fluids (CSF) of neurology patients but no CSF studies with psychiatric patients exist. We tested serum from 100 hospitalized psychotic patients having hallucinations and/or delusions for aPL. Patients with positive serum aPL findings were asked to submit CSF for aPL testing. Five CSF samples had aPL specificities not found in the patient's serum suggesting the possibility of intrathecal synthesis. Specificity and isotype discordance between CSF and blood aPL in these psychiatric patients implicates a central nervous system independent autoimmune process that may have an underlying association with the pathophysiology of their diseases.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalJournal of Neuroimmunology
Issue number1-2
StatePublished - Oct 1 2007


  • Autoantibodies
  • Bipolar disorder
  • Central nervous system
  • Schizophrenia

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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