Antiphospholipid autoantibodies as blood biomarkers for detection of early stage Alzheimer's disease

John A. McIntyre, Curtis J. Ramsey, Bruce D. Gitter, Andrew J. Saykin, Dawn R. Wagenknecht, Paul A. Hyslop

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A robust blood biomarker is urgently needed to facilitate early prognosis for those at risk for Alzheimer's disease (AD). Redox reactive autoantibodies (R-RAAs) represent a novel family of antibodies detectable only after exposure of cerebrospinal fluid (CSF), serum, plasma or immunoglobulin fractions to oxidizing agents. We have previously reported that R-RAA antiphospholipid antibodies (aPLs) are significantly decreased in the CSF and serum of AD patients compared to healthy controls (HCs). These studies were extended to measure R-RAA aPL in serum samples obtained from Alzheimer's Disease Neuroimaging Initiative (ADNI). Serum samples from the ADNI-1 diagnostic groups from participants with mild cognitive impairment (MCI), AD and HCs were blinded for diagnosis and analyzed for R-RAA aPL by ELISA. Demographics, cognitive data at baseline and yearly follow-up were subsequently provided by ADNI after posting assay data. As observed in CSF, R-RAA aPL in sera from the AD diagnostic group were significantly reduced compared to HC. However, the sera from the MCI population contained significantly elevated R-RAA aPL activity relative to AD patient and/or HC sera. The data presented in this study indicate that R-RAA aPL show promise as a blood biomarker for detection of early AD, and warrant replication in a larger sample. Longitudinal testing of an individual for increases in R-RAA aPL over a previously established baseline may serve as a useful early sero-epidemiologic blood biomarker for individuals at risk for developing dementia of the Alzheimer's type.

Original languageEnglish (US)
Pages (from-to)344-351
Number of pages8
Issue number5
StatePublished - Aug 1 2015


  • Mild cognitive impairment
  • Neurodegenerative disease
  • Redox-reactive antiphospholipid autoantibodies
  • Serum biomarkers

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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