Antiremodeling agents influence osteoblast activity differently in modeling and remodeling sites of canine rib

M. R. Allen, H. Follet, M. Khurana, M. Sato, D. B. Burr

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Antiremodeling agents reduce bone loss in part through direct actions on osteoclasts. Their effects on osteoblasts and bone formation activity are less clear and may differ at sites undergoing modeling vs. remodeling. Skeletally mature intact beagles, 1-2 years old at the start of the study, were treated daily with clinically relevant doses of alendronate (0.10 or 0.20 mg/kg), risedronate (0.05 or 0.10 mg/kg), raloxifene (0.50 mg/kg), or vehicle (1 mL/kg). Dynamic bone formation parameters were histologically assessed on periosteal, endocortical/trabecular, and intracortical bone envelopes of the rib. Raloxifene significantly increased periosteal surface mineral apposition rate (MAR), a measure of osteoblast activity, compared to all other treatments (+108 to +175%, P < 0.02), while having no significant effect on MAR at either the endocortical/trabecular or intracortical envelope. Alendronate (both 0.10 and 0.20 doses) and risedronate (only the 0.10 dose) significantly (P ≤ 0.05) suppressed MAR on the endocortical/trabecular envelope, while none of the bisphosphonate doses significantly altered MAR at either the periosteal or intracortical envelopes compared to vehicle. Based on these results, we conclude that (1) at clinically relevant doses the two classes of antiremodeling agents, bisphosphonates and selective estrogen receptor modulators, exert differential effects on osteoblast activity in the canine rib and (2) this effect depends on whether modeling or remodeling is the predominant mechanism of bone formation.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalCalcified Tissue International
Volume79
Issue number4
DOIs
StatePublished - Oct 1 2006

Keywords

  • Alendronate
  • Bisphosphonate
  • Periosteal
  • Raloxifene
  • Risedronate

ASJC Scopus subject areas

  • Endocrinology

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