Antiretroviral treatment interruptions induced by the Kenyan postelection crisis are associated with virological failure

Marita Mann, Lameck Diero, Emmanuel Kemboi, Fidelis Mambo, Mary Rono, Wilfred Injera, Allison Delong, Leeann Schreier, Kara W. Kaloustian, John Sidle, Nathan Buziba, Rami Kantor

Research output: Contribution to journalArticle

Abstract

BACKGROUND:: Antiretroviral treatment interruptions (TIs) cause suboptimal clinical outcomes. Data on TIs during social disruption are limited. METHODS:: We determined effects of unplanned TIs after the 2007-2008 Kenyan postelection violence on virological failure, comparing viral load (VL) outcomes in HIV-infected adults with and without conflict-induced TI. RESULTS:: Two hundred and one patients were enrolled, median 2.2 years after conflict and 4.3 years on treatment. Eighty-eight patients experienced conflict-related TIs and 113 received continuous treatment. After adjusting for preconflict CD4, patients with TIs were more likely to have detectable VL, VL >5,000 and VL >10,000. CONCLUSIONS:: Unplanned conflict-related TIs are associated with increased likelihood of virological failure.

Original languageEnglish
Pages (from-to)220-224
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume64
Issue number2
DOIs
StatePublished - Oct 1 2013

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Viral Load
Therapeutics
Violence
HIV

Keywords

  • Drug resistance
  • HIV
  • Political crisis Kenya
  • Treatment interruption
  • Virological failure

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Antiretroviral treatment interruptions induced by the Kenyan postelection crisis are associated with virological failure. / Mann, Marita; Diero, Lameck; Kemboi, Emmanuel; Mambo, Fidelis; Rono, Mary; Injera, Wilfred; Delong, Allison; Schreier, Leeann; Kaloustian, Kara W.; Sidle, John; Buziba, Nathan; Kantor, Rami.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 64, No. 2, 01.10.2013, p. 220-224.

Research output: Contribution to journalArticle

Mann, Marita ; Diero, Lameck ; Kemboi, Emmanuel ; Mambo, Fidelis ; Rono, Mary ; Injera, Wilfred ; Delong, Allison ; Schreier, Leeann ; Kaloustian, Kara W. ; Sidle, John ; Buziba, Nathan ; Kantor, Rami. / Antiretroviral treatment interruptions induced by the Kenyan postelection crisis are associated with virological failure. In: Journal of Acquired Immune Deficiency Syndromes. 2013 ; Vol. 64, No. 2. pp. 220-224.
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AU - Rono, Mary

AU - Injera, Wilfred

AU - Delong, Allison

AU - Schreier, Leeann

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AU - Buziba, Nathan

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