Antisense oligonucleotide therapy for TTR amyloidosis

M. D. Benson, S. Pandey, D. Witchell, A. Jazayeri, A. Siwkowski, B. Monia, B. Kluve-Beckerman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Hairy cell leukemia is a monoclonal B-lymphocyte disorder and, therefore, may be associated with production of systemic monoclonal immunoglobulin light chains, the first and foremost requirement of AL amyloidosis. A 73-year-old Caucasian man presented with macroglossia, ecchymosis, and heart failure. Fat pad aspirate was positive for amyloid. At age 53, the patient had developed hairy cell leukemia that responded initially to splenectomy. Subsequently, recurrence of disease required treatment with 2-chlorodeoxyadenosine (CDA), which gave good clinical response. His present illness is characterized by typical AL amyloidosis, and bone marrow histology is consistent with multiple myeloma.

Original languageEnglish (US)
Pages (from-to)60
Number of pages1
JournalAmyloid
Volume18
Issue numberSUPPL. 1
DOIs
StatePublished - Jun 2011

ASJC Scopus subject areas

  • Internal Medicine

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