Antistress activity of Butea monosperma flowers

A. D. Bhatwadekar, S. D. Chintawar, N. A. Logade, R. S. Somani, Veena S. Kasture, S. B. Kasture

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Objective: To investigate the antistress activity of water soluble part of ethanolic extract of Butea monosperma on water immersion stress-induced ulceration, elevation of serotonin (5-HT) in brain and corticosterone in plasma in rats. Methods: Stress was induced by forcing rats (n = 5) to swim in water for 2 hours and brain 5-HT and plasma corticosterone were estimated using a fluorimetric method. The rats received the extract (100, 200 or 400 mg/kg) or diazepam (0.2 mg/kg) i.p. 30 min before stress. Results: Water soluble part of ethanolic extract of flowers of Butea monosperma (100-400 mg/kg i.p.) attenuated water immersion stress induced elevation of brain serotonin and plasma corticosterone levels. The ulcer index also decreased in dose dependent manner. Diazepam (0.2 mg/kg i.p.) which was used as a reference standard exhibited similar effects. Conclusion: Butea monosperma flowers possess antistress activity. The observed effects may be due to decrease in brain 5-HT and suppression of hypothalamo-hypophyseal- adrenocortical axis.

Original languageEnglish (US)
Pages (from-to)153-155
Number of pages3
JournalIndian Journal of Pharmacology
Volume31
Issue number2
StatePublished - Apr 1999
Externally publishedYes

Keywords

  • Butea monosperma
  • Corticosterone
  • Serotonin
  • Stres
  • Ulcer

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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