Antistress activity of Butea monosperma flowers

Ashay Bhatwadekar, S. D. Chintawar, N. A. Logade, R. S. Somani, Veena S. Kasture, S. B. Kasture

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: To investigate the antistress activity of water soluble part of ethanolic extract of Butea monosperma on water immersion stress-induced ulceration, elevation of serotonin (5-HT) in brain and corticosterone in plasma in rats. Methods: Stress was induced by forcing rats (n = 5) to swim in water for 2 hours and brain 5-HT and plasma corticosterone were estimated using a fluorimetric method. The rats received the extract (100, 200 or 400 mg/kg) or diazepam (0.2 mg/kg) i.p. 30 min before stress. Results: Water soluble part of ethanolic extract of flowers of Butea monosperma (100-400 mg/kg i.p.) attenuated water immersion stress induced elevation of brain serotonin and plasma corticosterone levels. The ulcer index also decreased in dose dependent manner. Diazepam (0.2 mg/kg i.p.) which was used as a reference standard exhibited similar effects. Conclusion: Butea monosperma flowers possess antistress activity. The observed effects may be due to decrease in brain 5-HT and suppression of hypothalamo-hypophyseal- adrenocortical axis.

Original languageEnglish (US)
Pages (from-to)153-155
Number of pages3
JournalIndian Journal of Pharmacology
Volume31
Issue number2
StatePublished - Jan 1 1999
Externally publishedYes

Fingerprint

Butea
Serotonin
Corticosterone
Brain
Immersion
Diazepam
Dehydration
Water
Ulcer

Keywords

  • Butea monosperma
  • Corticosterone
  • Serotonin
  • Stres
  • Ulcer

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Bhatwadekar, A., Chintawar, S. D., Logade, N. A., Somani, R. S., Kasture, V. S., & Kasture, S. B. (1999). Antistress activity of Butea monosperma flowers. Indian Journal of Pharmacology, 31(2), 153-155.

Antistress activity of Butea monosperma flowers. / Bhatwadekar, Ashay; Chintawar, S. D.; Logade, N. A.; Somani, R. S.; Kasture, Veena S.; Kasture, S. B.

In: Indian Journal of Pharmacology, Vol. 31, No. 2, 01.01.1999, p. 153-155.

Research output: Contribution to journalArticle

Bhatwadekar, A, Chintawar, SD, Logade, NA, Somani, RS, Kasture, VS & Kasture, SB 1999, 'Antistress activity of Butea monosperma flowers', Indian Journal of Pharmacology, vol. 31, no. 2, pp. 153-155.
Bhatwadekar A, Chintawar SD, Logade NA, Somani RS, Kasture VS, Kasture SB. Antistress activity of Butea monosperma flowers. Indian Journal of Pharmacology. 1999 Jan 1;31(2):153-155.
Bhatwadekar, Ashay ; Chintawar, S. D. ; Logade, N. A. ; Somani, R. S. ; Kasture, Veena S. ; Kasture, S. B. / Antistress activity of Butea monosperma flowers. In: Indian Journal of Pharmacology. 1999 ; Vol. 31, No. 2. pp. 153-155.
@article{d9e59ed66ecc4a228b333678f25032e2,
title = "Antistress activity of Butea monosperma flowers",
abstract = "Objective: To investigate the antistress activity of water soluble part of ethanolic extract of Butea monosperma on water immersion stress-induced ulceration, elevation of serotonin (5-HT) in brain and corticosterone in plasma in rats. Methods: Stress was induced by forcing rats (n = 5) to swim in water for 2 hours and brain 5-HT and plasma corticosterone were estimated using a fluorimetric method. The rats received the extract (100, 200 or 400 mg/kg) or diazepam (0.2 mg/kg) i.p. 30 min before stress. Results: Water soluble part of ethanolic extract of flowers of Butea monosperma (100-400 mg/kg i.p.) attenuated water immersion stress induced elevation of brain serotonin and plasma corticosterone levels. The ulcer index also decreased in dose dependent manner. Diazepam (0.2 mg/kg i.p.) which was used as a reference standard exhibited similar effects. Conclusion: Butea monosperma flowers possess antistress activity. The observed effects may be due to decrease in brain 5-HT and suppression of hypothalamo-hypophyseal- adrenocortical axis.",
keywords = "Butea monosperma, Corticosterone, Serotonin, Stres, Ulcer",
author = "Ashay Bhatwadekar and Chintawar, {S. D.} and Logade, {N. A.} and Somani, {R. S.} and Kasture, {Veena S.} and Kasture, {S. B.}",
year = "1999",
month = "1",
day = "1",
language = "English (US)",
volume = "31",
pages = "153--155",
journal = "Indian Journal of Pharmacology",
issn = "0253-7613",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "2",

}

TY - JOUR

T1 - Antistress activity of Butea monosperma flowers

AU - Bhatwadekar, Ashay

AU - Chintawar, S. D.

AU - Logade, N. A.

AU - Somani, R. S.

AU - Kasture, Veena S.

AU - Kasture, S. B.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Objective: To investigate the antistress activity of water soluble part of ethanolic extract of Butea monosperma on water immersion stress-induced ulceration, elevation of serotonin (5-HT) in brain and corticosterone in plasma in rats. Methods: Stress was induced by forcing rats (n = 5) to swim in water for 2 hours and brain 5-HT and plasma corticosterone were estimated using a fluorimetric method. The rats received the extract (100, 200 or 400 mg/kg) or diazepam (0.2 mg/kg) i.p. 30 min before stress. Results: Water soluble part of ethanolic extract of flowers of Butea monosperma (100-400 mg/kg i.p.) attenuated water immersion stress induced elevation of brain serotonin and plasma corticosterone levels. The ulcer index also decreased in dose dependent manner. Diazepam (0.2 mg/kg i.p.) which was used as a reference standard exhibited similar effects. Conclusion: Butea monosperma flowers possess antistress activity. The observed effects may be due to decrease in brain 5-HT and suppression of hypothalamo-hypophyseal- adrenocortical axis.

AB - Objective: To investigate the antistress activity of water soluble part of ethanolic extract of Butea monosperma on water immersion stress-induced ulceration, elevation of serotonin (5-HT) in brain and corticosterone in plasma in rats. Methods: Stress was induced by forcing rats (n = 5) to swim in water for 2 hours and brain 5-HT and plasma corticosterone were estimated using a fluorimetric method. The rats received the extract (100, 200 or 400 mg/kg) or diazepam (0.2 mg/kg) i.p. 30 min before stress. Results: Water soluble part of ethanolic extract of flowers of Butea monosperma (100-400 mg/kg i.p.) attenuated water immersion stress induced elevation of brain serotonin and plasma corticosterone levels. The ulcer index also decreased in dose dependent manner. Diazepam (0.2 mg/kg i.p.) which was used as a reference standard exhibited similar effects. Conclusion: Butea monosperma flowers possess antistress activity. The observed effects may be due to decrease in brain 5-HT and suppression of hypothalamo-hypophyseal- adrenocortical axis.

KW - Butea monosperma

KW - Corticosterone

KW - Serotonin

KW - Stres

KW - Ulcer

UR - http://www.scopus.com/inward/record.url?scp=0032940049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032940049&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032940049

VL - 31

SP - 153

EP - 155

JO - Indian Journal of Pharmacology

JF - Indian Journal of Pharmacology

SN - 0253-7613

IS - 2

ER -