Antitumor effects of bisphosphonates: Promising preclinical evidence

Theresa A. Guise

Research output: Contribution to journalReview article

91 Scopus citations

Abstract

The majority of patients with advanced cancer will ultimately develop bone metastases. The bone microenvironment provides fertile soil for a cycle of tumor growth and bone destruction that increases the risk of debilitating and potentially life-limiting skeletal-related events. Therefore, developing appropriate strategies to prevent bone metastases is critical. Bisphosphonates used to treat and prevent skeletal-related events resulting from multiple myeloma and bone metastases secondary to solid tumors, may also have direct and indirect antitumor effects. Emerging evidence from in vitro and in vivo preclinical studies in several tumor types suggests that bisphosphonates can reduce tumor burden in bone and soft tissue, inhibit angiogenesis, prevent tumor cell invasion and adhesion in bone, and induce tumor cell apoptosis. The powerful antiresorptive properties of bisphosphonates appear to directly prevent tumor cell growth and angiogenesis; in addition, combining bisphosphonates with cytotoxic chemotherapy may provide further antitumor synergies. Sequential application of cytotoxic chemotherapy (e.g., doxorubicin, paclitaxel, and gemcitabine) followed by bisphosphonates has been shown to induce significantly more tumor cell apoptosis than either agent alone in vitro and effectively inhibits tumor growth in vivo. Furthermore, in vivo data suggest that optimizing the dosing schedule may significantly increase survival. Overall, preclinical data suggesting that bisphosphonates have antitumor potential are promising and have provided the impetus for several ongoing clinical studies.

Original languageEnglish (US)
Pages (from-to)S19-S24
JournalCancer Treatment Reviews
Volume34
Issue numberSUPPL. 1
DOIs
StatePublished - May 16 2008
Externally publishedYes

Keywords

  • Bisphosphonates
  • Bone metastases
  • Pamidronate
  • Skeletal-related events
  • Zoledronic acid

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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