Anxiety proneness linked to epistatic loci in genome scan of human personality traits

C. R. Cloninger, P. Van Eerdewegh, A. Goate, H. J. Edenberg, J. Blangero, V. Hesselbrock, T. Reich, J. Nurnberger, M. Schuckit, B. Porjesz, R. Crowe, J. P. Rice, T. Foroud, T. R. Przybeck, L. Almasy, K. Bucholz, W. Wu, S. Shears, K. Carr, C. CroseC. Willig, J. Zhao, J. A. Tischfield, T. K. Li, P. M. Conneally, H. Begleiter

Research output: Contribution to journalArticlepeer-review

133 Scopus citations

Abstract

A genome-wide scan between normal human personality traits and a set of genetic markers at an average interval of 13 centimorgans was carried out in 758 pairs of siblings in 177 nuclear families of alcoholics. Personality traits were measured by the Tridimensional Personality Questionnaire. We detected significant linkage between the trait Harm Avoidance, a measure of anxiety proneness, and a locus on chromosome 8p21-23 that explained 38% of the trait variance. There was significant evidence of epistasis between the locus on 8p and others on chromosomes 18p, 20p, and 21q. These oligogenic interactions explained most of the variance in Harm Avoidance. There was suggestive evidence of epistasis in other personality traits. These results confirm the important influence of epistasis on human personality suggested by twin and adoption studies.

Original languageEnglish (US)
Pages (from-to)313-317
Number of pages5
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume81
Issue number4
DOIs
StatePublished - Jul 10 1998

Keywords

  • Alcoholism
  • Epistasis
  • Genome scan
  • Linkage
  • Personality

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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