Anxiogenic effects of noreleagnine a water soluble beta-carboline in rats

A. Shekhar, J. N. Hingtgen, J. A. DiMicco

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We tested noreleagnine, a beta-carboline which unlike other beta-carbolines remains in aqueous solution at physiological pH, as well as chlordiazepoxide, a traditional benzodiazepine, and their interaction with the benzodiazepine receptor antagonist RO 15-1788 in a modified approach schedule with two levels of conflict. Noreleagnine displayed pro-conflict activity characteristic of beta-carbolines and chlordiazepoxide elicited an anti-conflict effect, both of which were blocked by pretreatment with RO 15-1788. We believe this to be the first clear demonstration that noreleagnine has an anxiogenic effect and that this effect is mediated by its action on benzodiazepine receptors.

Original languageEnglish (US)
Pages (from-to)539-542
Number of pages4
JournalNeuropharmacology
Volume28
Issue number5
DOIs
StatePublished - May 1989

Keywords

  • anxiety
  • benzodiazepines
  • beta-carbolines
  • conflict

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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