Anxiogenic effects of noreleagnine a water soluble beta-carboline in rats

Anantha Shekhar, J. N. Hingtgen, J. A. DiMicco

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We tested noreleagnine, a beta-carboline which unlike other beta-carbolines remains in aqueous solution at physiological pH, as well as chlordiazepoxide, a traditional benzodiazepine, and their interaction with the benzodiazepine receptor antagonist RO 15-1788 in a modified approach schedule with two levels of conflict. Noreleagnine displayed pro-conflict activity characteristic of beta-carbolines and chlordiazepoxide elicited an anti-conflict effect, both of which were blocked by pretreatment with RO 15-1788. We believe this to be the first clear demonstration that noreleagnine has an anxiogenic effect and that this effect is mediated by its action on benzodiazepine receptors.

Original languageEnglish
Pages (from-to)539-542
Number of pages4
JournalNeuropharmacology
Volume28
Issue number5
DOIs
StatePublished - 1989

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norharman
Chlordiazepoxide
Carbolines
GABA-A Receptors
Water
Benzodiazepines
Appointments and Schedules
tryptoline

Keywords

  • anxiety
  • benzodiazepines
  • beta-carbolines
  • conflict

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Anxiogenic effects of noreleagnine a water soluble beta-carboline in rats. / Shekhar, Anantha; Hingtgen, J. N.; DiMicco, J. A.

In: Neuropharmacology, Vol. 28, No. 5, 1989, p. 539-542.

Research output: Contribution to journalArticle

Shekhar, Anantha ; Hingtgen, J. N. ; DiMicco, J. A. / Anxiogenic effects of noreleagnine a water soluble beta-carboline in rats. In: Neuropharmacology. 1989 ; Vol. 28, No. 5. pp. 539-542.
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