Aortic Stenosis, Idiopathic Gastrointestinal Bleeding, and Angiodysplasia: Is There an Association? A Methodologic Critique of the Literature

Thomas F. Imperiale, David F. Ransohoff

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

To assess the reported association between colonic angiodysplasia and aortic stenosis, we performed a quantitative and methodologic analysis of the literature. In four controlled studies that support an association between aortic stenosis and idiopathic gastrointestinal bleeding there are major methodologic deficiencies including the following: nonblinded data collection, noncomparable diagnostic examination, nonblinded ascertainment of exposure, and noncomparable demographic susceptibility. None of the studies directly assesses angiodysplasia. Additional case reports about aortic valve replacement used to treat bleeding from angiodysplasia are limited in number and in duration of follow-up. We conclude that the existing literature does not demonstrate an association between aortic stenosis and angiodysplasia. Further controlled evaluation of this topic would be useful.

Original languageEnglish (US)
Pages (from-to)1670-1676
Number of pages7
JournalGastroenterology
Volume95
Issue number6
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Keywords

  • AS
  • GIB
  • aortic stenosis
  • gastrointestinal bleeding

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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