Aortic stenosis, idiopathic gastrointestinal bleeding, and angiodysplasia

Is there and association? A methodologic critique of the literature

Thomas Imperiale, D. F. Ransohoff

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

To assess the reported association between colonic angiodysplasia and aortic stenosis, we performed a quantitative and methodologic analysis of the literature. In four controlled studies that support an association between aortic stenosis and idiopathic gastrointestinal bleeding there are major methodologic deficiencies including the following: nonblinded data collection, noncomparable diagnostic examination, nonblinded ascertainment of exposure, and noncomparable demographic susceptibility. None of the studies directly assesses angiodysplasia. Additional case reports about aortic valve replacement used to treat bleeding from angiodysplasia are limited in number and in duration of follow-up. We conclude that the existing literature does not demonstrate an association between aortic stenosis and angiodysplasia. Further controlled evaluation of this topic would be used.

Original languageEnglish (US)
Pages (from-to)1670-1676
Number of pages7
JournalGastroenterology
Volume95
Issue number6
StatePublished - 1988
Externally publishedYes

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Angiodysplasia
Aortic Valve Stenosis
Hemorrhage
Aortic Valve
Demography

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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AB - To assess the reported association between colonic angiodysplasia and aortic stenosis, we performed a quantitative and methodologic analysis of the literature. In four controlled studies that support an association between aortic stenosis and idiopathic gastrointestinal bleeding there are major methodologic deficiencies including the following: nonblinded data collection, noncomparable diagnostic examination, nonblinded ascertainment of exposure, and noncomparable demographic susceptibility. None of the studies directly assesses angiodysplasia. Additional case reports about aortic valve replacement used to treat bleeding from angiodysplasia are limited in number and in duration of follow-up. We conclude that the existing literature does not demonstrate an association between aortic stenosis and angiodysplasia. Further controlled evaluation of this topic would be used.

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