APOE ε4 and memory among patients with heart failure

Susan Pressler, Jordan M. Harrison, Marita Titler, Todd M. Koelling, Miyeon Jung, Susan G. Dorsey, Giorgos Bakoyannis, Penny L. Riley, Lisa Hoyland-Domenico, Bruno Giordani

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Twenty-three percent to 50% of heart failure (HF) patients have memory loss. Objectives were to (a) characterize major allelic frequency of 2 variants in apolipoprotein (APOE) gene in HF patients, (b) evaluate differences in memory and serum brain-derived neurotrophic factor (BDNF) levels based on APOE ε4 allele(s), and (c) estimate effect sizes (ESs) and confidence intervals (CIs). In this pilot, 29 HF patients were enrolled and 26 completed. Recall and delayed recall memory were measured at baseline and 12 weeks. Serum was collected at baseline and 8 weeks. Seven (24.1%) patients had APOE ε4 allele. No significant differences were found in recall and delayed recall memory or serum BDNF levels based on APOE ε4 allele. ESs were small to medium; CIs indicated ES precision was small. Future studies are needed to fully understand how genotypic and neuropsychological phenotypic variables influence response to computerized cognitive training.

Original languageEnglish (US)
Pages (from-to)455-472
Number of pages18
JournalWestern Journal of Nursing Research
Volume39
Issue number4
DOIs
StatePublished - 2017

Keywords

  • APOE ε4
  • Apolipoprotein E
  • BDNF
  • Brain-derived neurotrophic factor
  • Cognition
  • Heart failure
  • Memory

ASJC Scopus subject areas

  • Nursing(all)

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    Pressler, S., Harrison, J. M., Titler, M., Koelling, T. M., Jung, M., Dorsey, S. G., Bakoyannis, G., Riley, P. L., Hoyland-Domenico, L., & Giordani, B. (2017). APOE ε4 and memory among patients with heart failure. Western Journal of Nursing Research, 39(4), 455-472. https://doi.org/10.1177/0193945916670145