APOE ε4 is not associated with Alzheimer's disease in elderly Nigerians

Oye Gureje, Adesola Ogunniyi, Olusegun Baiyewu, Brandon Price, Frederick W. Unverzagt, Rebecca M. Evans, Valerie Smith-Gamble, Kathleen A. Lane, Sujuan Gao, Kathleen S. Hall, Hugh C. Hendrie, Jill R. Murrell

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Since 1992, research teams from Indiana University and the University of Ibadan have been collecting and comparing data from two diverse, elderly populations to identify risk factors for dementia and Alzheimer's disease. Apolipoprotein E (APOE) was genotyped in 2,245 Nigerian samples. Of these, 830 had a diagnosis: 459 were normal, and 140 had dementia including 123 diagnosed with Alzheimer's disease. In contrast with other populations, the APOE ε4 allele was not significantly associated with Alzheimer's disease or dementia. This lack of association in the Yoruba might reflect genetic variation, environmental factors, as well as genetic/environmental interactions.

Original languageEnglish (US)
Pages (from-to)182-185
Number of pages4
JournalAnnals of neurology
Volume59
Issue number1
DOIs
StatePublished - Jan 2006

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Gureje, O., Ogunniyi, A., Baiyewu, O., Price, B., Unverzagt, F. W., Evans, R. M., Smith-Gamble, V., Lane, K. A., Gao, S., Hall, K. S., Hendrie, H. C., & Murrell, J. R. (2006). APOE ε4 is not associated with Alzheimer's disease in elderly Nigerians. Annals of neurology, 59(1), 182-185. https://doi.org/10.1002/ana.20694