APOE genotype and neuroimaging markers of Alzheimer's disease: Systematic review and meta-analysis

Ying Liu, Jin Tai Yu, Hui Fu Wang, Pei Ran Han, Chen Chen Tan, Chong Wang, Xiang Fei Meng, Shannon L. Risacher, Andrew J. Saykin, Lan Tan

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Objective: We aimed to examine the association of apolipoprotein E (APOE) ε4 genotype with neuroimaging markers of Alzheimer's disease: hippocampal volume, brain amyloid deposition and cerebral metabolism. Methods: We performed a systematic review and metaanalysis of 14 cross-sectional studies identified in Pubmed from 1996 to 2014 (n=1628). The pooled standard mean difference (SMD) was used to estimate the association between APOE and hippocampal volume and amyloid deposition. Meta-analysis was performed using effect size signed differential mapping using coordinates extracted from clusters with statistically significant difference in cerebral metabolic rate for glucose between APOE ε4+ and ε4- groups. Results: APOE ε4 carrier status was associated with atrophic hippocampal volume (pooled SMD: -0.47; 95% CI -0.82 to -0.13; p=0.007) and increased cerebral amyloid positron emission tomography tracer ( pooled SMD: 0.62, 95% CI 0.27 to 0.98, p=0.0006). APOE ε4 was also associated with decreased cerebral metabolism, especially in right middle frontal gyrus. Conclusions: APOE ε4 was associated with atrophic hippocampal volume in MRI markers, increased cerebral amyloid deposition and cerebral hypometabolism. Theses associations may indicate the potential role of the APOE gene in the pathophysiology of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume86
Issue number2
DOIs
StatePublished - Feb 1 2015

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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    Liu, Y., Yu, J. T., Wang, H. F., Han, P. R., Tan, C. C., Wang, C., Meng, X. F., Risacher, S. L., Saykin, A. J., & Tan, L. (2015). APOE genotype and neuroimaging markers of Alzheimer's disease: Systematic review and meta-analysis. Journal of Neurology, Neurosurgery and Psychiatry, 86(2), 127-134. https://doi.org/10.1136/jnnp-2014-307719