APOE genotype and neuroimaging markers of Alzheimer's disease: Systematic review and meta-analysis

Ying Liu, Jin Tai Yu, Hui Fu Wang, Pei Ran Han, Chen Chen Tan, Chong Wang, Xiang Fei Meng, Shannon L. Risacher, Andrew Saykin, Lan Tan

Research output: Contribution to journalArticle

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Abstract

Objective: We aimed to examine the association of apolipoprotein E (APOE) ε4 genotype with neuroimaging markers of Alzheimer's disease: hippocampal volume, brain amyloid deposition and cerebral metabolism. Methods: We performed a systematic review and metaanalysis of 14 cross-sectional studies identified in Pubmed from 1996 to 2014 (n=1628). The pooled standard mean difference (SMD) was used to estimate the association between APOE and hippocampal volume and amyloid deposition. Meta-analysis was performed using effect size signed differential mapping using coordinates extracted from clusters with statistically significant difference in cerebral metabolic rate for glucose between APOE ε4+ and ε4- groups. Results: APOE ε4 carrier status was associated with atrophic hippocampal volume (pooled SMD: -0.47; 95% CI -0.82 to -0.13; p=0.007) and increased cerebral amyloid positron emission tomography tracer ( pooled SMD: 0.62, 95% CI 0.27 to 0.98, p=0.0006). APOE ε4 was also associated with decreased cerebral metabolism, especially in right middle frontal gyrus. Conclusions: APOE ε4 was associated with atrophic hippocampal volume in MRI markers, increased cerebral amyloid deposition and cerebral hypometabolism. Theses associations may indicate the potential role of the APOE gene in the pathophysiology of Alzheimer's disease.

Original languageEnglish
Pages (from-to)127-134
Number of pages8
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume86
Issue number2
DOIs
StatePublished - Feb 1 2015

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Apolipoprotein E4
Apolipoproteins E
Neuroimaging
Meta-Analysis
Alzheimer Disease
Amyloid
Genotype
PubMed
Positron-Emission Tomography
Cross-Sectional Studies
Deposition
Systematic Review
Alzheimer's Disease
Meta-analysis
Glucose
Brain
Metabolism
Genes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery
  • Arts and Humanities (miscellaneous)

Cite this

APOE genotype and neuroimaging markers of Alzheimer's disease : Systematic review and meta-analysis. / Liu, Ying; Yu, Jin Tai; Wang, Hui Fu; Han, Pei Ran; Tan, Chen Chen; Wang, Chong; Meng, Xiang Fei; Risacher, Shannon L.; Saykin, Andrew; Tan, Lan.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 86, No. 2, 01.02.2015, p. 127-134.

Research output: Contribution to journalArticle

Liu, Ying ; Yu, Jin Tai ; Wang, Hui Fu ; Han, Pei Ran ; Tan, Chen Chen ; Wang, Chong ; Meng, Xiang Fei ; Risacher, Shannon L. ; Saykin, Andrew ; Tan, Lan. / APOE genotype and neuroimaging markers of Alzheimer's disease : Systematic review and meta-analysis. In: Journal of Neurology, Neurosurgery and Psychiatry. 2015 ; Vol. 86, No. 2. pp. 127-134.
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