As a part of our ongoing study on Alzheimer's disease (AD) in elderly African Americans, we obtained clinical assessment and apolipoprotein E (ApoE) genotype data on 288 individuals (including 60 with AD). The ApoE ε4 allele frequency was significantly increased in AD patients compared with controls. The age-adjusted odds ratio (OR) for AD in ε4 homozygotes was 4.83 (95% confidence interval [CI], 1.71-13.64) compared with the ε3/ε3 genotype, but the OR for AD with the ε3/ε4 genotype did not reach significance (1.20; 95% CI, 0.582.65). These findings suggest that the association between ApoE ε4 and AD is weaker in African Americans than in whites.
ASJC Scopus subject areas
- Clinical Neurology