Apolipoprotein E-associated risk for Alzheimer's disease in the African- American population is genotype dependent

Amrik Sahota, Min Yang, Sujuan Gao, Siu L. Hui, Olusegun Baiyewu, Oyewusi Gureje, Steven Oluwole, Adesola Ogunniyi, Kathleen S. Hall, Hugh C. Hendrie

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

As a part of our ongoing study on Alzheimer's disease (AD) in elderly African Americans, we obtained clinical assessment and apolipoprotein E (ApoE) genotype data on 288 individuals (including 60 with AD). The ApoE ε4 allele frequency was significantly increased in AD patients compared with controls. The age-adjusted odds ratio (OR) for AD in ε4 homozygotes was 4.83 (95% confidence interval [CI], 1.71-13.64) compared with the ε3/ε3 genotype, but the OR for AD with the ε3/ε4 genotype did not reach significance (1.20; 95% CI, 0.582.65). These findings suggest that the association between ApoE ε4 and AD is weaker in African Americans than in whites.

Original languageEnglish (US)
Pages (from-to)659-661
Number of pages3
JournalAnnals of neurology
Volume42
Issue number4
DOIs
StatePublished - Oct 1 1997

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Apolipoprotein E-associated risk for Alzheimer's disease in the African- American population is genotype dependent'. Together they form a unique fingerprint.

  • Cite this