Apolipoprotein E-associated risk for Alzheimer's disease in the African- American population is genotype dependent

Amrik Sahota, Min Yang, Sujuan Gao, Siu Hui, Olusegun Baiyewu, Oyewusi Gureje, Steven Oluwole, Adesola Ogunniyi, Kathleen Hall, Hugh Hendrie

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Abstract

As a part of our ongoing study on Alzheimer's disease (AD) in elderly African Americans, we obtained clinical assessment and apolipoprotein E (ApoE) genotype data on 288 individuals (including 60 with AD). The ApoE ε4 allele frequency was significantly increased in AD patients compared with controls. The age-adjusted odds ratio (OR) for AD in ε4 homozygotes was 4.83 (95% confidence interval [CI], 1.71-13.64) compared with the ε3/ε3 genotype, but the OR for AD with the ε3/ε4 genotype did not reach significance (1.20; 95% CI, 0.582.65). These findings suggest that the association between ApoE ε4 and AD is weaker in African Americans than in whites.

Original languageEnglish
Pages (from-to)659-661
Number of pages3
JournalAnnals of Neurology
Volume42
Issue number4
DOIs
StatePublished - Oct 1997

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Apolipoproteins E
African Americans
Alzheimer Disease
Genotype
Apolipoprotein E4
Population
Odds Ratio
Confidence Intervals
Homozygote
Gene Frequency

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Apolipoprotein E-associated risk for Alzheimer's disease in the African- American population is genotype dependent. / Sahota, Amrik; Yang, Min; Gao, Sujuan; Hui, Siu; Baiyewu, Olusegun; Gureje, Oyewusi; Oluwole, Steven; Ogunniyi, Adesola; Hall, Kathleen; Hendrie, Hugh.

In: Annals of Neurology, Vol. 42, No. 4, 10.1997, p. 659-661.

Research output: Contribution to journalArticle

Sahota, Amrik ; Yang, Min ; Gao, Sujuan ; Hui, Siu ; Baiyewu, Olusegun ; Gureje, Oyewusi ; Oluwole, Steven ; Ogunniyi, Adesola ; Hall, Kathleen ; Hendrie, Hugh. / Apolipoprotein E-associated risk for Alzheimer's disease in the African- American population is genotype dependent. In: Annals of Neurology. 1997 ; Vol. 42, No. 4. pp. 659-661.
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