Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy

C. Michael Cotten, Ricki F. Goldstein, Scott A. McDonald, Ronald N. Goldberg, Walid A. Salhab, Waldemar A. Carlo, Jon E. Tyson, Neil N. Finer, Michele C. Walsh, Richard A. Ehrenkranz, Abbot R. Laptook, Ronnie Guillet, Kurt Schibler, Krisa P. Van Meurs, Brenda B. Poindexter, Barbara J. Stoll, T. Michael O'Shea, Shahnaz Duara, Abhik Das, Rosemary D. HigginsSeetha Shankaran

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Adults with the apolipoprotein E (APOE) gene alleles e4 and e2 are at high risk of poor neurological outcome after brain injury. The e4 allele has been associated with cerebral palsy (CP), and the e2 allele has been associated with worse neurological outcome with congenital heart disease. This study was done to test the hypothesis that the APOE genotype is associated with outcome among neonates who survive after hypoxic-ischemic encephalopathy (HIE). Methods: We conducted a cohort study of infants who survived HIE and had 18-22 mo standardized neurodevelopmental evaluations to assess associations between disability and the APOE genotypes e3/e3, e4/-, and e2/-. Results: A total of 139 survivors were genotyped. Of these, 86 (62%) were of the e3/e3, 41 (29%) were of the e4/-, and 14 (10%) were of the e2/- genotypes. One hundred and twenty-nine infants had genotype and follow-up data; 26% had moderate or severe disabilities. Disability prevalence was 30 and 19% among those with and without the e3/e3 genotype, 25 and 26% among those with and without the e2 allele, and 18 and 29% among those with and without the e4 allele, respectively. None of the differences were statistically significant. CP prevalence was also similar among genotype groups. Conclusion: Disability was not associated with the APOE genotype in this cohort of HIE survivors.

Original languageEnglish
Pages (from-to)424-430
Number of pages7
JournalPediatric Research
Volume75
Issue number3
DOIs
StatePublished - Mar 2014

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Brain Hypoxia-Ischemia
Apolipoproteins E
Genotype
Alleles
Cerebral Palsy
Survivors
Brain Injuries
Heart Diseases
Cohort Studies
Newborn Infant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Cotten, C. M., Goldstein, R. F., McDonald, S. A., Goldberg, R. N., Salhab, W. A., Carlo, W. A., ... Shankaran, S. (2014). Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy. Pediatric Research, 75(3), 424-430. https://doi.org/10.1038/pr.2013.235

Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy. / Cotten, C. Michael; Goldstein, Ricki F.; McDonald, Scott A.; Goldberg, Ronald N.; Salhab, Walid A.; Carlo, Waldemar A.; Tyson, Jon E.; Finer, Neil N.; Walsh, Michele C.; Ehrenkranz, Richard A.; Laptook, Abbot R.; Guillet, Ronnie; Schibler, Kurt; Van Meurs, Krisa P.; Poindexter, Brenda B.; Stoll, Barbara J.; O'Shea, T. Michael; Duara, Shahnaz; Das, Abhik; Higgins, Rosemary D.; Shankaran, Seetha.

In: Pediatric Research, Vol. 75, No. 3, 03.2014, p. 424-430.

Research output: Contribution to journalArticle

Cotten, CM, Goldstein, RF, McDonald, SA, Goldberg, RN, Salhab, WA, Carlo, WA, Tyson, JE, Finer, NN, Walsh, MC, Ehrenkranz, RA, Laptook, AR, Guillet, R, Schibler, K, Van Meurs, KP, Poindexter, BB, Stoll, BJ, O'Shea, TM, Duara, S, Das, A, Higgins, RD & Shankaran, S 2014, 'Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy', Pediatric Research, vol. 75, no. 3, pp. 424-430. https://doi.org/10.1038/pr.2013.235
Cotten CM, Goldstein RF, McDonald SA, Goldberg RN, Salhab WA, Carlo WA et al. Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy. Pediatric Research. 2014 Mar;75(3):424-430. https://doi.org/10.1038/pr.2013.235
Cotten, C. Michael ; Goldstein, Ricki F. ; McDonald, Scott A. ; Goldberg, Ronald N. ; Salhab, Walid A. ; Carlo, Waldemar A. ; Tyson, Jon E. ; Finer, Neil N. ; Walsh, Michele C. ; Ehrenkranz, Richard A. ; Laptook, Abbot R. ; Guillet, Ronnie ; Schibler, Kurt ; Van Meurs, Krisa P. ; Poindexter, Brenda B. ; Stoll, Barbara J. ; O'Shea, T. Michael ; Duara, Shahnaz ; Das, Abhik ; Higgins, Rosemary D. ; Shankaran, Seetha. / Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy. In: Pediatric Research. 2014 ; Vol. 75, No. 3. pp. 424-430.
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abstract = "Background: Adults with the apolipoprotein E (APOE) gene alleles e4 and e2 are at high risk of poor neurological outcome after brain injury. The e4 allele has been associated with cerebral palsy (CP), and the e2 allele has been associated with worse neurological outcome with congenital heart disease. This study was done to test the hypothesis that the APOE genotype is associated with outcome among neonates who survive after hypoxic-ischemic encephalopathy (HIE). Methods: We conducted a cohort study of infants who survived HIE and had 18-22 mo standardized neurodevelopmental evaluations to assess associations between disability and the APOE genotypes e3/e3, e4/-, and e2/-. Results: A total of 139 survivors were genotyped. Of these, 86 (62{\%}) were of the e3/e3, 41 (29{\%}) were of the e4/-, and 14 (10{\%}) were of the e2/- genotypes. One hundred and twenty-nine infants had genotype and follow-up data; 26{\%} had moderate or severe disabilities. Disability prevalence was 30 and 19{\%} among those with and without the e3/e3 genotype, 25 and 26{\%} among those with and without the e2 allele, and 18 and 29{\%} among those with and without the e4 allele, respectively. None of the differences were statistically significant. CP prevalence was also similar among genotype groups. Conclusion: Disability was not associated with the APOE genotype in this cohort of HIE survivors.",
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T1 - Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy

AU - Cotten, C. Michael

AU - Goldstein, Ricki F.

AU - McDonald, Scott A.

AU - Goldberg, Ronald N.

AU - Salhab, Walid A.

AU - Carlo, Waldemar A.

AU - Tyson, Jon E.

AU - Finer, Neil N.

AU - Walsh, Michele C.

AU - Ehrenkranz, Richard A.

AU - Laptook, Abbot R.

AU - Guillet, Ronnie

AU - Schibler, Kurt

AU - Van Meurs, Krisa P.

AU - Poindexter, Brenda B.

AU - Stoll, Barbara J.

AU - O'Shea, T. Michael

AU - Duara, Shahnaz

AU - Das, Abhik

AU - Higgins, Rosemary D.

AU - Shankaran, Seetha

PY - 2014/3

Y1 - 2014/3

N2 - Background: Adults with the apolipoprotein E (APOE) gene alleles e4 and e2 are at high risk of poor neurological outcome after brain injury. The e4 allele has been associated with cerebral palsy (CP), and the e2 allele has been associated with worse neurological outcome with congenital heart disease. This study was done to test the hypothesis that the APOE genotype is associated with outcome among neonates who survive after hypoxic-ischemic encephalopathy (HIE). Methods: We conducted a cohort study of infants who survived HIE and had 18-22 mo standardized neurodevelopmental evaluations to assess associations between disability and the APOE genotypes e3/e3, e4/-, and e2/-. Results: A total of 139 survivors were genotyped. Of these, 86 (62%) were of the e3/e3, 41 (29%) were of the e4/-, and 14 (10%) were of the e2/- genotypes. One hundred and twenty-nine infants had genotype and follow-up data; 26% had moderate or severe disabilities. Disability prevalence was 30 and 19% among those with and without the e3/e3 genotype, 25 and 26% among those with and without the e2 allele, and 18 and 29% among those with and without the e4 allele, respectively. None of the differences were statistically significant. CP prevalence was also similar among genotype groups. Conclusion: Disability was not associated with the APOE genotype in this cohort of HIE survivors.

AB - Background: Adults with the apolipoprotein E (APOE) gene alleles e4 and e2 are at high risk of poor neurological outcome after brain injury. The e4 allele has been associated with cerebral palsy (CP), and the e2 allele has been associated with worse neurological outcome with congenital heart disease. This study was done to test the hypothesis that the APOE genotype is associated with outcome among neonates who survive after hypoxic-ischemic encephalopathy (HIE). Methods: We conducted a cohort study of infants who survived HIE and had 18-22 mo standardized neurodevelopmental evaluations to assess associations between disability and the APOE genotypes e3/e3, e4/-, and e2/-. Results: A total of 139 survivors were genotyped. Of these, 86 (62%) were of the e3/e3, 41 (29%) were of the e4/-, and 14 (10%) were of the e2/- genotypes. One hundred and twenty-nine infants had genotype and follow-up data; 26% had moderate or severe disabilities. Disability prevalence was 30 and 19% among those with and without the e3/e3 genotype, 25 and 26% among those with and without the e2 allele, and 18 and 29% among those with and without the e4 allele, respectively. None of the differences were statistically significant. CP prevalence was also similar among genotype groups. Conclusion: Disability was not associated with the APOE genotype in this cohort of HIE survivors.

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