Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans

Hugh Hendrie, Kathleen Hall, Siu Hui, Frederick Unverzagt, C. E. Yu, Debomoy Lahiri, A. Sahota, Martin Farlow, B. Musick, C. A. Class, A. Brashear, V. E. Burdine, B. O. Osuntokun, A. O. Ogunniyi, O. Gureje, O. Baiyewu, G. D. Schellenberg

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Abstract

As part of a community-based study of Alzheimer's disease (AD) in the African-American population age 65 and over, we have determined apolipoprotein E (Apo E) genotypes in 85 subjects (31 AD patients and 54 controls). The ε4 allele of Apo E was strongly associated with AD in this population sample. The ε4 allele frequency in AD patients was 40.3% compared with 13.9% in the control group, and 22.6% of the AD patients were homozygous for this allele compared with 3.7% of the control subjects (p = 0.01). This study extends the association of Apo E-ε4 and AD to nonwhite populations and provides further evidence that the observed allelic association is biologically relevant.

Original languageEnglish
Pages (from-to)118-120
Number of pages3
JournalAnnals of Neurology
Volume37
Issue number1
DOIs
StatePublished - Jan 1995

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Apolipoproteins E
African Americans
Alzheimer Disease
Genotype
Apolipoprotein E4
Alleles
Population
Gene Frequency
Control Groups

ASJC Scopus subject areas

  • Neuroscience(all)

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Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans. / Hendrie, Hugh; Hall, Kathleen; Hui, Siu; Unverzagt, Frederick; Yu, C. E.; Lahiri, Debomoy; Sahota, A.; Farlow, Martin; Musick, B.; Class, C. A.; Brashear, A.; Burdine, V. E.; Osuntokun, B. O.; Ogunniyi, A. O.; Gureje, O.; Baiyewu, O.; Schellenberg, G. D.

In: Annals of Neurology, Vol. 37, No. 1, 01.1995, p. 118-120.

Research output: Contribution to journalArticle

Hendrie, H, Hall, K, Hui, S, Unverzagt, F, Yu, CE, Lahiri, D, Sahota, A, Farlow, M, Musick, B, Class, CA, Brashear, A, Burdine, VE, Osuntokun, BO, Ogunniyi, AO, Gureje, O, Baiyewu, O & Schellenberg, GD 1995, 'Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans', Annals of Neurology, vol. 37, no. 1, pp. 118-120. https://doi.org/10.1002/ana.410370123
Hendrie, Hugh ; Hall, Kathleen ; Hui, Siu ; Unverzagt, Frederick ; Yu, C. E. ; Lahiri, Debomoy ; Sahota, A. ; Farlow, Martin ; Musick, B. ; Class, C. A. ; Brashear, A. ; Burdine, V. E. ; Osuntokun, B. O. ; Ogunniyi, A. O. ; Gureje, O. ; Baiyewu, O. ; Schellenberg, G. D. / Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans. In: Annals of Neurology. 1995 ; Vol. 37, No. 1. pp. 118-120.
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